What is it about?

Type 1 diabetes and LADA are autoimmune diseases with loss of immune tolerance and reduced function and number of beta cells. DPP-inhibitors and vitamin D3 have effects about immune system and beta cells, and therefore may have beneficial effects when associated to treat autoimmune diabetes.

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Why is it important?

DPP-inhibitors and vitamin D3 are safe medicines and with little adverse effects, with effects about immune system and beta cells can be a new treatment to autoimmune diabetes because this association is not an imunusupression treatment, but an immunomodulation together with beta cells stimulation. In addition, both medicines decrease beta cells apoptosis, that is increased in the type 1 diabetes and LADA.

Perspectives

We believe that this association when used in new-onset type 1 diabetes and new-onset LADA can help to preserve beta cell function with safety and low cost. In addition, can help to prevent other autoimmune diseases that can occur togehther with autoimmune diabetes.

MD MARCELO M PINHEIRO
Univag - University Center

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This page is a summary of: Dipeptidyl peptidase-4 inhibitors (DPP-4i) combined with vitamin D3: An exploration to treat new-onset type 1 diabetes mellitus and latent autoimmune diabetes in adults in the future, International Immunopharmacology, April 2018, Elsevier, DOI: 10.1016/j.intimp.2018.02.003.
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