What is it about?
This work combines oxidation with mass spectrometry of a membrane protein to determine membrane exposed oxidised residues, which have a larger mass, from those residues that are buried in the membrane bilayer.
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Why is it important?
We reveal a rapid tool to identify the topology of a membrane protein, the first step to begin understanding structure-function of membrane proteins
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This page is a summary of: Validation of Membrane Protein Topology Models by Oxidative Labeling and Mass Spectrometry, Journal of the American Society for Mass Spectrometry, March 2012, American Chemical Society (ACS),
DOI: 10.1007/s13361-012-0342-x.
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