Computational Models for Neglected Diseases: Gaps and Opportunities

  • Elizabeth L. Ponder, Joel S. Freundlich, Malabika Sarker, Sean Ekins
  • Pharmaceutical Research, August 2013, Springer Science + Business Media
  • DOI: 10.1007/s11095-013-1170-9

Gaps in neglected disease research

What is it about?

Neglected diseases affect millions of patients and primarily are in the worlds poorest countries. We need to do more R&D to find treatments and computational methods can help. We discuss which methods have / have not been used for each disease.

Why is it important?

Computational methods are cheaper than traditional wet science research. We can in some cases transfer discoveries from one neglected disease to another depending on the organism. The amount of money spent on these diseases is dwarfed by what the drug companies spend on blockbuster diseases so we need to leverage what tools we can. Models depend on data and in some cases this is absent. Sharing models and tools would be a good place to start. Too many models are used in isolation.

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http://dx.doi.org/10.1007/s11095-013-1170-9

The following have contributed to this page: Dr Sean Ekins and Joel Freundlich