What is it about?
This is the continuation of our previous work where we found new polymorph of metacetamol. Now thermal analysis was applied to control formation of new polymorph. Metacetamol II does not form with cooling rates of 24, 12 or 3 K/min, only at 6K/min. Cooling faster or slower - one will get more stable metacetamol I. Tricky, but interesting polymorphism story!
Featured Image
Why is it important?
This is one of rare examples how cooling rate influence crystallization of iether stable or metastable polymorph. Metacetamol is also a structural isomer of paracetamol, which also shows polymorphism during thermal changes
Perspectives
Formation of the new phase of metacetamol II could be studied with other physico-chemical methods. It is important and interesting to understand which factors and why direct the formation of the new phase
Dr Denis A. Rychkov
Novosibirsk State University, ISSC SB RAS
Read the Original
This page is a summary of: Cooling rate “window” in the crystallization of metacetamol form II, Journal of Thermal Analysis and Calorimetry, November 2016, Springer Science + Business Media,
DOI: 10.1007/s10973-016-5954-0.
You can read the full text:
Resources
Contributors
The following have contributed to this page
