Expression of protein-coding genes by a kinase that binds directly to the genes

What is it about?

The target of rapamycin complex 1 controls gene expression in response to a variety of signals, including amino acid sufficiency and stress. This review considers recent evidence that this kinase may do so, not only indirectly by phosphorylation of cognate transcription factors, but by direct binding to target genes.

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Why is it important?

Since dysregulation of this kinase is linked to a variety of diseases, it is important to understand its mode of action.