What is it about?
This is a great book put together by Steve Olson and Farshid Guilak. It covers Post-Traumatic Arthritis, including its management and the most up-to-date research. We provided the chapter on non-invasive mouse models of ACL rupture to initiate arthritis pathogenesis, and summarize what can be learned from this model.
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Why is it important?
The book is a comprehensive presentation of the current thinking on all aspects of how joint injury mechanistically affects the subsequent development of Arthritis. Our chapter summarizes what we have learned from our mouse ACL-rupture model, which is especially suited for studying the very earliest changes that occur minutes to hours after injury.
Perspectives
Intuitively people understand that their 'bum knee' likely resulted from a previous injury. Scientifically, we have yet to identify how an injury from a long time ago connects with today's osteoarthritis. The field of osteoarthritis research is moving toward studying what happens within the joint early after an injury. Once we understand the injury responses, we can start to manipulate these therapeutically with the hopes of altering the disease trajectory and delaying or preventing future OA.
Professor Dominik R Haudenschild
Houston Methodist
Read the Original
This page is a summary of: Closed Joint ACL Disruption Murine Model of PTA, January 2015, Springer Science + Business Media,
DOI: 10.1007/978-1-4899-7606-2_7.
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