What is it about?
T. cruzi shares a unique antioxidant defence system. Tryparedoxin peroxidase has been identified as a constituent of the complex peroxidase system in the trypanosomatid Crithidia fasciculata . In trypanosomatids, hydroperoxides are reduced at the expense of NADPH by means of a cascade of three oxidoreductases: the flavoprotein trypanothione reductase, tryparedoxin and tryparedoxin peroxidase. Inhibitors of these enzymes are presumed to be trypanocidal drugs.
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Why is it important?
Excellent opportunities for reliable large-scale screening of inhibitors.
Perspectives
Chagas disease treatment
Dr. Jorge A. López
Read the Original
This page is a summary of: His-tagged tryparedoxin peroxidase of Trypanosoma cruzi as a tool for drug screening, Applied Microbiology and Biotechnology, April 2000, Springer Science + Business Media,
DOI: 10.1007/s002530051634.
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