What is it about?
Makes some practical points about dose escalation designs.
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Why is it important?
The necessity of making decisions in real time about whether to escalate doses or not means that the utility of such designs cannot be judged by considering their efficiency on the assumption that they will proceed to enroll subjects on the highest dose.
Read the Original
This page is a summary of: Commentary on ‘Designs for dose–escalation trials with quantitative responses’, Statistics in Medicine, December 2009, Wiley,
DOI: 10.1002/sim.3735.
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