What is it about?
When concurrent controls are used, like is being compared with like as regards the centres, medical staff, measurement processes used and patients recruited. However, these can vary from trial to trial so that when historical data are used, they are not controlled for. This raises issues regarding analysis and trust that require careful planning and reporting. The paper gives practical advice on these issues.
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Why is it important?
Gives practical advice on an important issue and avoids unnecessary technical complication in doing so.
Perspectives
I had been worried for some years about the lack of concern on the issues outlined in this paper. It was a pleasure to be able to join the lead of Olivier Collignon and together with the other co-authors to address these concerns. Above all our aims were to be clear and practical in the advice given
Professor Stephen J Senn
Consultant Statistician
Read the Original
This page is a summary of: Implementing Historical Controls in Oncology Trials, The Oncologist, March 2021, Oxford University Press (OUP),
DOI: 10.1002/onco.13696.
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