What is it about?
Male infertility induced by hypoxia mainly correlate with the apoptosis of spermatocytes. We have shown for the first time that hypoxia-induced apoptosis of mouse spermatocytes is mediated by HIF-1α through a death receptor pathway and a mitochondrial pathway. This paper examines the mechanism of male infertility induced by hypoxia.
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Why is it important?
our data suggest that the death receptor pathway and mitochondrial pathway, which are likely mediated by HIF-1α, contribute to hypoxia-induced GC-2 cell apoptosis. Thus HIF-1α is an important intervention target in the process of impaired spermatogenesis induced by hypoxia.
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This page is a summary of: Hypoxia-induced apoptosis of mouse spermatocytes is mediated by HIF-1α through a death receptor pathway and a mitochondrial pathway, Journal of Cellular Physiology, June 2017, Wiley,
DOI: 10.1002/jcp.25974.
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