What is it about?
Post-translational modifications like S-nitrosylation via nitric oxide changes cofilin-1 activity to regulate actin cytoskeleton reorganization and thus increasing cell motility and migration in response to VEGF in endothelial cells.
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Why is it important?
NO is an important gaseous signaling molecule that regulates Cell migration via modification of protein functions on reactive cysteines. Cell migration is fundamental to many physiological and pathophysiological processes.
Perspectives
S-nitrosylation of cofilin-1 offers a pathway for mediating enhanced cell migration in angiogenesis in physiological processes and pathological processes in association with increased VEGF production.
Dongbao Chen
Read the Original
This page is a summary of: S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration, Journal of Cellular Physiology, October 2014, Wiley,
DOI: 10.1002/jcp.24724.
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