What is it about?
Hyperosmolar induced cell death is an important issue as corneal epithelium is exposed to hyperosmolar stimulation in the common dry eye disease. We found that a ubiquitous protein, transglutaminase-2, is an important player in the hyperosmolar induced death in this context.
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Photo by National Cancer Institute on Unsplash
Why is it important?
Transglutaminase-2 may form the basis of protective cell therapy in dry eye disease.
Perspectives
Transglutaminase may regulate mitochondrial mediated cell death.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Hyperosmolarity‐mediated mitochondrial dysfunction requires Transglutaminase‐2 in human Corneal epithelial cells, Journal of Cellular Physiology, December 2010, Wiley,
DOI: 10.1002/jcp.22389.
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