What is it about?
Disordered eating with caloric excess (obesity) or caloric restriction (anorexia nervosa) is associated with detriments to metabolic and bone health. Both excess and restricted calories are marked by an increased bone fat, but such accrual has variable effects on bone quantity and response to exercise. In this study, we show that obesity increases a fat depot in the bone, and this depot behaves much like abdominal and other fat depots. Exercise is able to reduce the size of this fat depot and burn it for fuel and at the same time build stronger, larger bones.
Why is it important?
Bone marrow fat is thought to be important to bone health because it is increased in states of bone fragility, such as osteoporosis. However, the physiologic purpose of bone fat and its regulation are poorly understood. An improved understanding of the function of bone marrow fat will enable the development of future therapies to improve bone health.
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This page is a summary of: Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice, Journal of Bone and Mineral Research, May 2017, Wiley, DOI: 10.1002/jbmr.3159.
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