What is it about?
As a frequently used drug -to achieve genetic manipulation in mice - Tamoxifen has been used in many biomedical fields, including the bone field. We found that tamoxifen, even at very low doses, significantly increases bone quantity. Thus, tamoxifen is likely to confound studies of bone in transgenic mouse models.
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Why is it important?
Transgenic mouse models have been critical in furthering our understanding of and treatment for a variety of diseases. Inducible models (like those induced by the drug tamoxifen) are attractive because the genetic manipulation can be induced in adult mice , and in specific tissues as well. Although we did not anticipate to find a tamoxifen-effect when we initiated this work , originally aimed at understanding beta catenin in bone, our follow up investigations confirmed the initial findings of a dose-dependent increase in bone quantity with tamoxifen.
Perspectives
For translational research in the bone field, unexpected findings are of great interest ! I hope that our work will be methodologically impactful to improving experimental design in the bone field
Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology
Read the Original
This page is a summary of: Low Dose Tamoxifen Induces Significant Bone Formation in Mice, JBMR Plus, December 2020, Wiley,
DOI: 10.1002/jbm4.10450.
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