What is it about?

A 45 year old male patient with debilitating fractures that occurred for several years prior to a diagnosis and a cure (surgery) for TIO.

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Why is it important?

Important to consider TIO when assessing younger individuals with unexplained fractures and low phosphorus. Providers should consider that a normal FGF23 might not exclude the diagnosis.


In addition to thee importance of recognizing and diagnosing this condition, our patient had an interesting family history of a musculoskeletal malignancy [chondrosarcoma in his mother] and therefore this raises the question of whether genetic predisposition might underlie some cases of TIO.

Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology

Read the Original

This page is a summary of: A Normal FGF23 Does Not Preclude Tumor Induced Osteomalacia ( TIO ), JBMR Plus, November 2020, Wiley, DOI: 10.1002/jbm4.10438.
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