What is it about?
CXCL12 secreted by CAFs activates CXCL12/CXCR4 signal and trigger integrin beta1 clustering on the cell membrane in gastric cancer.
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Why is it important?
CXCL12 activates not only CXCL12/CXCR4 signal but also integrin beta 1 - extracellular matrix signal, and CXCR4 antagonist inhibit both of them.
Perspectives
AMD3100 (CXCR4 antagonist) have potential to be a therapeutic agent in gastric cancer.
Dr Daisuke Izumi
Graduate School of Medical Sciences, Kumamoto University
Read the Original
This page is a summary of: CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, International Journal of Cancer, October 2015, Wiley,
DOI: 10.1002/ijc.29864.
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