What is it about?
It is a work on the characterization of an experimental model to study colon carcinogenesis, the Pirc rats mutated in a gene important in colon cancer
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Why is it important?
The gene Apc is mutated in the majority of colon cancer and it is the cause of Familial Adenomatous Polyposis, a genetic disease at high risk of colon cancer, therefore this rat may be an useful tool to study colon carcinogenesis and to test preventive drugs/dietary components
Perspectives
At variance with existing model of intestinal carcinogenesis, like Min mice developing tumours in the samll intestine, Pirc rats develops tumours in the colon, thus they are an useful tool to study colon carcinogenesis and to test preventive drugs/dietary components
Dr Giovanna Caderni
University of Florence
Read the Original
This page is a summary of: Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated inApc, International Journal of Cancer, October 2014, Wiley,
DOI: 10.1002/ijc.29232.
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