What is it about?
PNPLA3 mutation reduces PPARg activity in HSC and makes it more fibrotic
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Why is it important?
PPAR gamma activators are known to be important in fatty liver disease but were considered to be important by their impact on insulin sensitivity and fatty acid storage, but we showed that they might also reduce fibrogenesis directly in HSC
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This page is a summary of: The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells, Hepatology, April 2017, Wiley,
DOI: 10.1002/hep.29041.
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