Acid‐Free Synthesis of Carbazoles and Carbazolequinones by Intramolecular Pd‐Catalyzed, Microwave‐Assisted Oxidative Biaryl Coupling Reactions – Efficient Syntheses of Murrayafoline A, 2‐Methoxy‐3‐methylcarbazole, and Glycozolidine

What is it about?

A mild and efficient methodology for the synthesis of oxy- genated carbazoles from diarylamines under non-acidic con- ditions was developed, based on a palladium-catalyzed, mi- crowave-assisted double C–H bond activation process. This new protocol was successfully applied to the synthesis of three naturally occurring carbazoles, namely murrayafoline A, 2-methoxy-3-methylcarbazole, and glycozolidine.

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Why is it important?

The scope of the reaction was also expanded to include the syn- thesis of benzo fused carbazolequinones.