What is it about?
In this study we treated diabetes prone mice with adenovirus engineered to express a synthetic member of the IL-12 cytokine family which we designated IL-Y. The synthetic cytokine suppressed the development of diabetes in these mice through a mechanism that antagonize the pro-inflammatory helper T cells prevalent in these mice and actively involved in the pathogenesis of disease.
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Why is it important?
Our data demonstrated that a novel synthetic member of the IL-12 family was immunosuppressive and could have therapeutic application for autoimmune diseases. Given that the subunits for IL-Y are naturally produced by immune cells, the synthetic pairing of the IL-Y subunits would not invoke an allergic immune response and thus no complication would be anticipated.
Perspectives
It was fun to determine the biological affects this synthetic cytokine had on various diseases and it was gratifying to discover that IL-Y had a positive effect in suppressing autoimmune diabetes.
Dr Rafael R. Flores
The Scripps Research Institute Florida
Read the Original
This page is a summary of: IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice, European Journal of Immunology, September 2015, Wiley,
DOI: 10.1002/eji.201445403.
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