What is it about?
Herein we discuss the (pre)clinical evidence that points to the involvement of circadian rhythm disruption (by light noise, shift work and jet-lag) in accelerating or even instigating the pathological changes in the brain.
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Why is it important?
Chronotherapy and circadian rhythm alignment can significantly improve the outcome of therapeutics and slow down the progression of neurodegenerative diseases (AD, HD and PD) in predisposed patients.
Perspectives
Writing this article gave us an immense pleasure, reviewing published evidence for our hypothesis was an illuminating experience. I hope this article generates an interest in researchers to factor in circadian rhythms disruption while diagnosing or treating various neurodegenerative disorders.
Dr Ashish Sharma
School of Pharmaceutical Sciences, Shoolini University
Read the Original
This page is a summary of: Do Circadian Rhythms Draw the Patterns of Sustained Mental Vigor and Ailment?, Drug Development Research, September 2016, Wiley,
DOI: 10.1002/ddr.21342.
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