What is it about?
This study is a project for the newly established global consortium, the International Hundred K+ Cohorts Consortium. Polygenic risk scores have significant potential to inform clinical risk, however, research efforts in minor populations are warranted to avoid health disparities. We present an international collaborative effort on the development of a trans-ethnic PRS for BMI.
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Why is it important?
While polygenic risk scores hold significant promise in estimating an individual’s risk of developing a complex trait such as obesity, their application in the clinic has, to date, been limited by a lack of data from non-European populations.
Perspectives
As the first effort by the IHCC to leverage the existing datasets that reside within this large scale consortium for a trans-ethnic PRS on BMI, we envision an opportunity to scale this to other cohorts within the consortium and expand the number of traits that can be analyzed.
Dr. Hui-Qi Qu
Children's Hospital of Philadelphia
Read the Original
This page is a summary of: Trans‐ethnic polygenic risk scores for body mass index: An international hundred K+ cohorts consortium study, Clinical and Translational Medicine, June 2023, Wiley,
DOI: 10.1002/ctm2.1291.
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