What is it about?

Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo‐aging. Across the solar radiation spectrum, UV light is the main cause behind skin problems. UV damages are hampered by the generation of reactive oxygen species (ROS) that in turn also depress immune system. Nowadays UV damages are reduced by the use of UV filters that themselves become reactive molecules absorbing UV radiation. We have developed and patented a whole new class of molecules capable to act as UV protecting boosters in the regards of traditional UV filters and to work both as potent antioxidants. Publication cover image Volume12, Issue10 May 22, 2017 Pages 760-769 This article also appears in: MedChemSicily 2018 Figures References Related Information Metrics Article has an altmetric score of 1 Details © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

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Why is it important?

The multitarget approach is important to reduce the number of molecules to be used and to obtain a multiplication of the expected effect by hitting different targets that works on the same problem

Perspectives

This project is conduced in an optics to improve efficacy of sunscreens against skin melanoma

Prof Stefano Manfredini
University of Ferrara

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This page is a summary of: A Multitarget Approach toward the Development of 8-Substituted Purines for Photoprotection and Prevention of UV-Related Damage, ChemMedChem, May 2017, Wiley,
DOI: 10.1002/cmdc.201700137.
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