All Stories

  1. Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity

    Article • European Journal of Medicinal Chemistry, August 2018, Elsevier

    Prof Stefano Manfredini

  2. Combination of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate for the treatment of inflammatory lung diseases: An in vitro study

    Article • European Journal of Pharmaceutical Sciences, April 2018, Elsevier

    Prof Stefano Manfredini

  3. Moringa oleifera Leaf Extracts as Multifunctional Ingredients for “Natural and Organic” Sunscreens and Photoprotective Preparations

    Article • Molecules, March 2018, MDPI AG

    Prof Stefano Manfredini

  4. Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study

    Article • Molecules, November 2017, MDPI AG

    Prof Stefano Manfredini

  5. A Multitarget Approach for Photoprotection and Prevention of Sun Exposure Related Damage

    Article • ChemMedChem, May 2017, Wiley

    Prof Stefano Manfredini

  6. Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review

    Article • Fitoterapia, October 2016, Elsevier

    Prof Stefano Manfredini

  7. Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum

    Article • Molecules, September 2016, MDPI AG

    Prof Stefano Manfredini

  8. New insights into sugar characterization in complex plant matrices by high-performance thin-layer chromatography

    Article • Journal of Liquid Chromatography &amp Related Technologies, August 2016, Taylor & Francis

    Prof Stefano Manfredini

  9. Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

    Article • Molecules, April 2016, MDPI AG

    Prof Stefano Manfredini

  10. Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

    Article • Scientific Reports, December 2015, Nature

    Prof Stefano Manfredini

  11. Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells

    Article • European Journal of Pharmaceutical Sciences, October 2015, Elsevier

    Prof Stefano Manfredini

  12. Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

    Article • European Journal of Medicinal Chemistry, October 2015, Elsevier

    Prof Stefano Manfredini

  13. Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

    Article • European Journal of Medicinal Chemistry, August 2015, Elsevier

    Prof Stefano Manfredini

  14. A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

    Article • Molecules, June 2015, MDPI AG

    Prof Stefano Manfredini

  15. Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties

    Article • Bioorganic & Medicinal Chemistry, January 2015, Elsevier

    Prof Stefano Manfredini

  16. Retraction notice to: “Design, synthesis, and antioxidant potency of novel α-tocopherol analogues in isolated membranes and intact cells” [Free Radical Biology & Medicine 44 (2008) 1452–1464]

    Article • Free Radical Biology and Medicine, October 2014, Elsevier

    Prof Stefano Manfredini

  17. Encapsulation of Satureja montana essential oil in β-cyclodextrin

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, August 2014, Springer Science + Business Media

    Prof Stefano Manfredini

  18. High-Performance Thin-Layer Chromatography (HPTLC): a New Green Approach to Soluble Fiber Determination in Plant Matrices

    Article • Food Analytical Methods, April 2014, Springer Science + Business Media

    Prof Stefano Manfredini

  19. Evaluation of Antiradical Activity of Different Cocoa and Chocolate Products: Relation with Lipid and Protein Composition

    Article • Journal of Medicinal Food, April 2014, Mary Ann Liebert Inc

    Prof Stefano Manfredini

  20. Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Professor Gianfranco Balboni, Prof Stefano Manfredini, Ayyalusamy Ramamoorthy

  21. Antioxidant Activity of Cosmetic Formulations Based on Novel Extracts from Seeds of Brazilian <i>Araucaria angustifolia</i> (Bertoll) Kuntze

    Article • Journal of Cosmetics Dermatological Sciences and Applications, January 2014, Scientific Research Publishing, Inc,

    Prof Stefano Manfredini

  22. Oxidative Stress and Erythrocyte Membrane Alterations in Children with Autism: Correlation with Clinical Features

    Article • PLoS ONE, June 2013, PLOS

    Prof Stefano Manfredini

  23. Frataxin mRNA Isoforms in FRDA Patients and Normal Subjects: Effect of Tocotrienol Supplementation

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Prof Stefano Manfredini

  24. Modulation of the Expression of the Proinflammatory IL-8 Gene in Cystic Fibrosis Cells by Extracts Deriving from Olive Mill Waste Water

    Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

    Prof Stefano Manfredini

  25. Dualistic Properties of Cosmetic Formulations Based on Phenylpropanoids from <i>Ajuga reptans</i>

    Article • Journal of Cosmetics Dermatological Sciences and Applications, January 2013, Scientific Research Publishing, Inc,

    Prof Stefano Manfredini

  26. Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications

    Article • Molecules, November 2012, MDPI AG

    Prof Stefano Manfredini

  27. Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives

    Article • European Journal of Medicinal Chemistry, August 2012, Elsevier

    Prof Stefano Manfredini

  28. Synthetic Studies toward C-Glucosidic Ellagitannins: A Biomimetic Total Synthesis of 5-O-Desgalloylepipunicacortein A

    Article • Chemistry - A European Journal, June 2012, Wiley

    Prof Stefano Manfredini

  29. Novel molecular combination deriving from natural aminoacids and polyphenols: Design, synthesis and free-radical scavenging activities

    Article • European Journal of Medicinal Chemistry, April 2012, Elsevier

    Prof Stefano Manfredini

  30. ChemInform Abstract: Rapid Access to 1-Benzyl 2-Substituted Piperazines: Application to the Synthesis of 1-Benzyl-2-difluoromethyl-piperazine.

    Article • ChemInform, December 2011, Wiley

    Prof Stefano Manfredini

  31. Activity and Stability Studies of Verbascoside, a Novel Antioxidant, in Dermo-Cosmetic and Pharmaceutical Topical Formulations

    Article • Molecules, August 2011, MDPI AG

    Prof Stefano Manfredini

  32. Rapid Access to 1-Benzyl 2-Substituted Piperazines: Application to the Synthesis of 1-Benzyl-2-difluoromethyl-Piperazine

    Article • Synthetic Communications, July 2011, Taylor & Francis

    Prof Stefano Manfredini

  33. Antidermatophytic activity of pyrazolo[3,4-c]isothiazoles: a preliminary approach on 4-chlorophenyl derivative for evaluation of mutagenic and clastogenic effects on bacteria and human chromosomesin vitro

    Article • Drug and Chemical Toxicology, June 2011, Informa Healthcare

    Prof Stefano Manfredini

  34. Pyrazolo[3,4-c]isothiazole and isothiazolo[4,3-d]isoxazole derivatives as antifungal agents

    Article • Pharmaceutical Biology, March 2011, Taylor & Francis

    Prof Stefano Manfredini

  35. Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress

    Article • Free Radical Biology and Medicine, November 2010, Elsevier

    Prof Stefano Manfredini

  36. Synthesis of 3-azabicyclo[4.1.0]heptane-1-carboxylic acid

    Article • Tetrahedron, July 2010, Elsevier

    Prof Stefano Manfredini

  37. ChemInform Abstract: A New Synthetic Approach to Pyrazolo[3,4-c]-1,2,5-oxadiazoles.

    Article • ChemInform, June 2010, Wiley

    Prof Stefano Manfredini

  38. ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors.

    Article • ChemInform, May 2010, Wiley

    Prof Stefano Manfredini

  39. First synthesis of 2,6-diazabicyclo[3.2.0]heptane derivatives

    Article • Tetrahedron Letters, December 2009, Elsevier

    Prof Stefano Manfredini

  40. Quorum sensing inhibition activity of garlic extract andp-coumaric acid

    Article • Letters in Applied Microbiology, November 2009, Wiley

    Prof Stefano Manfredini

  41. Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

    Article • Molecules, August 2009, MDPI AG

    Prof Stefano Manfredini

  42. ChemInform Abstract: 7-Deazainosine Derivatives: Synthesis and Characterization of 7- and 7,8-Substituted Pyrrolo[2,3-d]pyrimidine Ribonucleosides.

    Article • ChemInform, October 2008, Wiley

    Prof Stefano Manfredini

  43. Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

    Article • Molecules, May 2008, MDPI AG

    Prof Stefano Manfredini

  44. 7-Deazainosine Derivatives: Synthesis and Characterization of 7- and 7,8-Substituted Pyrrolo [2,3-d]Pyrimidine Ribonucleosides

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2008, Taylor & Francis

    Prof Stefano Manfredini

  45. RETRACTED: Design, synthesis, and antioxidant potency of novel α-tocopherol analogues in isolated membranes and intact cells

    Article • Free Radical Biology and Medicine, April 2008, Elsevier

    Prof Stefano Manfredini

  46. New Coordination Modes ofL-Ascorbic Acid and Dehydro-L-ascorbic Acid as Dianionic Chelating Ligand for Platinum

    Article • European Journal of Inorganic Chemistry, February 2008, Wiley

    Prof Stefano Manfredini

  47. Design, Synthesis and Anti Flaviviridae Activity of N6-, 5′,3′-O- and 5′,2′-O-Substituted Adenine Nucleoside Analogs

    Article • Chemical and Pharmaceutical Bulletin, January 2008, Pharmaceutical Society of Japan

    Professor Sabrina Pricl, Prof Stefano Manfredini

  48. Effects of new combinative antioxidant FeAOX-6 and α-tocotrienol on macrophage atherogenesis-related functions

    Article • Vascular Pharmacology, June 2007, Elsevier

    Prof Stefano Manfredini

  49. Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich Ataxia

    Article • Molecular and Cellular Biochemistry, May 2007, Springer Science + Business Media

    Prof Stefano Manfredini

  50. Novel selective human mitochondrial kinase inhibitors: Design, synthesis and enzymatic activity

    Article • Bioorganic & Medicinal Chemistry, April 2007, Elsevier

    Prof Stefano Manfredini

  51. Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer

    Article • Molecular Cancer, January 2007, Springer Science + Business Media

    Prof Stefano Manfredini

  52. The use of photochemiluminescence for the measurement of the integral antioxidant capacity of baobab products

    Article • Food Chemistry, January 2007, Elsevier

    Prof Stefano Manfredini

  53. A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S�)

    Article • Skin Research and Technology, November 2006, Wiley

    Prof Stefano Manfredini

  54. Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents

    Article • Bioorganic & Medicinal Chemistry Letters, November 2006, Elsevier

    Prof Stefano Manfredini

  55. Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells

    Article • Molecular and Cellular Biochemistry, April 2006, Springer Science + Business Media

    Prof Stefano Manfredini

  56. Nanoparticle formulation may affect the stabilization of an antiischemic prodrug

    Article • International Journal of Pharmaceutics, January 2006, Elsevier

    Prof Stefano Manfredini

  57. Antioxidant effect of FeAOX-6 on free radical species produced during iron catalyzed breakdown oftert-butyl hydroperoxide

    Article • Free Radical Research, January 2006, Taylor & Francis

    Prof Stefano Manfredini

  58. Hypolipidaemic activity of aqueous ocimum basilicum extract in acute hyperlipidaemia induced by triton WR-1339 in rats and its antioxidant property

    Article • Phytotherapy Research, January 2006, Wiley

    Prof Stefano Manfredini

  59. Adenosine Phosphonoacetic Acid is Slowly Metabolized by NDP Kinase

    Article • Medicinal Chemistry, November 2005, Bentham Science Publishers

    Prof Stefano Manfredini

  60. Synthetic Approaches to a Mononucleotide Prodrug of Cytarabine

    Article • Nucleosides Nucleotides & Nucleic Acids, September 2005, Taylor & Francis

    Prof Stefano Manfredini

  61. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods

    Article • Food Chemistry, August 2005, Elsevier

    Prof Stefano Manfredini

  62. Synthesis and biological evaluation of pro-drugs of GW196771, a potent glycine antagonist acting at the NMDA receptor

    Article • Il Farmaco, May 2005, Elsevier

    Prof Stefano Manfredini

  63. Development and characterization of biodegradable nanospheres as delivery systems of anti-ischemic adenosine derivatives

    Article • Biomaterials, April 2005, Elsevier

    Prof Stefano Manfredini

  64. Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs

    Article • European Journal of Pharmaceutical Sciences, March 2005, Elsevier

    Prof Stefano Manfredini

  65. Vitamin C and 6-amino-vitamin C conjugates of diclofenac: synthesis and evaluation

    Article • International Journal of Pharmaceutics, March 2005, Elsevier

    Prof Stefano Manfredini

  66. In vitro neuroprotection by novel antioxidants in guinea-pig urinary bladder subjected to anoxia-glucopenia/reperfusion damage

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, November 2004, Springer Science + Business Media

    Prof Stefano Manfredini

  67. Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules

    Article • Bioorganic & Medicinal Chemistry, October 2004, Elsevier

    Prof Stefano Manfredini

  68. Composition and Functional Properties of the Essential Oil of Amazonian Basil,Ocimum micranthumWilld., Labiatae in Comparison with Commercial Essential Oils

    Article • Journal of Agricultural and Food Chemistry, June 2004, American Chemical Society (ACS)

    Prof Stefano Manfredini

  69. The Antioxidants and Pro-Antioxidants Network: An Overview

    Article • Current Pharmaceutical Design, May 2004, Bentham Science Publishers

    Prof Stefano Manfredini

  70. Hindered nucleoside analogs as antiflaviviridae agents

    Article • Pure and Applied Chemistry, January 2004, De Gruyter

    Professor Sabrina Pricl, Prof Stefano Manfredini

  71. Transporter-Mediated Effects of Diclofenamic Acid and its Ascorbyl Pro-Drug in the in Vivo Neurotropic Activity of Ascorbyl Nipecotic Acid Conjugate

    Article • Journal of Pharmaceutical Sciences, January 2004, Elsevier

    Prof Stefano Manfredini

  72. Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements

    Article • Skin Research and Technology, July 2003, Wiley

    Prof Stefano Manfredini

  73. Capillary Electrophoresis Determination, Synthesis, and Stability of Resveratrol and Related 3- O -β- d -Glucopyranosides

    Article • Journal of Agricultural and Food Chemistry, December 2002, American Chemical Society (ACS)

    Prof Stefano Manfredini

  74. Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties

    Article • Free Radical Biology and Medicine, December 2002, Elsevier

    Prof Stefano Manfredini

  75. Adenosine A1 Receptor: Analysis of the Potential Therapeutic Effects Obtained by its Activation in the Central Nervous System

    Article • Current Medicinal Chemistry, November 2002, Bentham Science Publishers

    Prof Stefano Manfredini

  76. Design, Synthesis and Activity of Ascorbic Acid Prodrugs of Nipecotic, Kynurenic and Diclophenamic Acids, Liable to Increase Neurotropic Activity

    Article • Journal of Medicinal Chemistry, January 2002, American Chemical Society (ACS)

    Prof Stefano Manfredini

  77. Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, May 2001, Elsevier

    Prof Stefano Manfredini

  78. 2′-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase

    Article • Biochemical Pharmacology, March 2001, Elsevier

    Prof Stefano Manfredini

  79. Article • Pharmaceutical Research, January 2001, Springer Science + Business Media

    Prof Stefano Manfredini

  80. Novel antioxidant agents deriving from molecular combinations of vitamins C and E analogues: 3,4-dihydroxy-5(R)-[2(R,S)-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2(R,S)-yl-methyl)-[1,3]dioxolan-4(S)-yl]-5H-furan-2-one and 3-O-octadecyl derivatives

    Article • Bioorganic & Medicinal Chemistry, December 2000, Elsevier

    Prof Stefano Manfredini

  81. ChemInform Abstract: Pyrazole Related Nucleosides. Part 5. Synthesis and Biological Activity of 2′-Deoxy-2′,3′-dideoxy- and Acyclo-Analogues of 4-Iodo-1-β-D-ribofuranosyl-3-carboxymethylpyrazole (IPCAR).

    Article • ChemInform, October 2000, Wiley

    Prof Stefano Manfredini

  82. Pyrazolo-triazoles as light activable dna cleaving agents

    Article • Bioorganic & Medicinal Chemistry, September 2000, Elsevier

    Prof Stefano Manfredini

  83. Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1′-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1′-substituted-acetoxymethyl)-2-dioxolanyl] dialkyl amines

    Article • Bioorganic & Medicinal Chemistry, July 2000, Elsevier

    Prof Stefano Manfredini

  84. Pyrazole Related Nucleosides 5.1Synthesis and Biological Activity of 2′-Deoxy- 2′, 3′-dideoxy- and Acyclo-analogues of 4-Iodo-1-β-D-ribofuranosyl-3-carboxymethyl Pyrazole (IPCAR)

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2000, Taylor & Francis

    Prof Stefano Manfredini

  85. Peptide T-araC conjugates: solid-phase synthesis and biological activity of N4-(acylpeptidyl)-araC

    Article • Bioorganic & Medicinal Chemistry, March 2000, Elsevier

    Prof Stefano Manfredini

  86. A New Synthetic Approach to Pyrazolo[3,4-c]-1,2,5-oxadiazoles

    Article • Synthesis, January 2000, Thieme Publishing Group

    Prof Stefano Manfredini

  87. Synthesis, in Vitro Antiproliferative Activity, and DNA-Binding Properties of Hybrid Molecules Containing Pyrrolo[2,1- c ][1,4]benzodiazepine and Minor-Groove-Binding Oligopyrrole Carriers

    Article • Journal of Medicinal Chemistry, December 1999, American Chemical Society (ACS)

    Prof Stefano Manfredini

  88. Heterocyclic Derivatives ofall-transRetinoic Acid:in vitroEffects on Fibroblast/Keratinocyte Growth and Differentiation, andin vivoEffects on Guinea-Pig Skin

    Article • Pharmacology & Toxicology, October 1999, Wiley

    Prof Stefano Manfredini

  89. 5‘-Phosphoramidates and 5‘-Diphosphates of 2‘- O -Allyl-β- d -arabinofuranosyl- uracil, -cytosine, and -adenine:  Inhibition of Ribonucleotide Reductase

    Article • Journal of Medicinal Chemistry, August 1999, American Chemical Society (ACS)

    Prof Stefano Manfredini

  90. Prodrugs of Ara-CMP and Ara-AMP with aS-Acyl-2-thioethyl (SATE) Biolabile Phosphate Protecting Group: Synthesis and Biological Evaluation

    Article • Nucleosides and Nucleotides, April 1999, Taylor & Francis

    Prof Stefano Manfredini

  91. Synthesis, Cytostatic Activity and Inhibition of Ribonucleotide Reductase by 5′-Phosphoramidates and 5′-Diphosphates, of 2′-O-Allyl-arabinofuranosyl Nucleosides

    Article • Nucleosides and Nucleotides, April 1999, Taylor & Francis

    Prof Stefano Manfredini

  92. Synthesis and Anti-HSV-1 Activity of 6 Substituted Pyrazolo[3,4-d]Pyridazin-7-one Nucleosides

    Article • Nucleosides and Nucleotides, December 1998, Taylor & Francis

    Prof Stefano Manfredini

  93. A Mild One-Pot Synthesis of Thieno[3,4-c]pyrazoles and Their Conversion into Pyrazole Analogs of o-Quinodimethane

    Article • Synthesis, September 1998, Thieme Publishing Group

    Prof Stefano Manfredini

  94. Synthesis and Biological Evaluation of a Series of Substituted Pyrazolo[3,4-d]-1,2,3-triazoles and Pyrazolo[3,4-d]oxazoles

    Article • Archiv der Pharmazie, September 1998, Wiley

    Prof Stefano Manfredini

  95. Synthesis and Biological Evaluation of a Series of Substituted Pyrazolo[3,4-d]-1,2,3-triazoles and Pyrazolo[3,4-d]oxazoles

    Article • Archiv der Pharmazie, September 1998, Wiley

    Prof Stefano Manfredini

  96. Retinoic Acid Conjugates as Potential Antitumor Agents:  Synthesis and Biological Activity of Conjugates with Ara-A, Ara-C, 3(2 H )-Furanone, and Aniline Mustard Moieties

    Article • Journal of Medicinal Chemistry, November 1997, American Chemical Society (ACS)

    Prof Stefano Manfredini

  97. Facile synthesis of 2-nitroalkanols by tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones

    Article • Tetrahedron Letters, April 1997, Elsevier

    Prof Stefano Manfredini

  98. Synthesis and antiproliferative activity of 2′-O-allyl-1-β-D-arabinofuranosyl-uracil, -cytosine and -adenine

    Article • Bioorganic & Medicinal Chemistry Letters, February 1997, Elsevier

    Prof Stefano Manfredini

  99. De Novo Biosynthesis of Purines

    Article • Emerging Therapeutic Targets, January 1997, Informa Healthcare

    Prof Stefano Manfredini

  100. Prevention of Free Radical Oxidative Damage

    Article • Emerging Therapeutic Targets, January 1997, Informa Healthcare

    Prof Stefano Manfredini

  101. Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines

    Article • Tetrahedron Letters, July 1996, Elsevier

    Prof Stefano Manfredini

  102. Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds

    Article • Bioorganic & Medicinal Chemistry Letters, June 1996, Elsevier

    Prof Stefano Manfredini

  103. A PLE-based resolution of cocaine, pseudococaine, and 6- and 7-methoxylated cocaine analogues

    Article • Bioorganic & Medicinal Chemistry Letters, February 1996, Elsevier

    Prof Stefano Manfredini

  104. Unusual Ring-Opening Reaction of 6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-dione Derivatives Leading to 5-(Alkylthio)-6-vinyluracils

    Article • The Journal of Organic Chemistry, March 1995, American Chemical Society (ACS)

    Prof Stefano Manfredini

  105. Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine

    Article • Journal of Medicinal Chemistry, January 1995, American Chemical Society (ACS)

    Prof Stefano Manfredini

  106. Cholinergic Agents Structurally Related to Furtrethonium. 2. Synthesis and Antimuscarinic Activity of a Series of N-[5-[(1'-Substituted-acetoxy)methyl]-2-furfuryl]dialkylamines

    Article • Journal of Medicinal Chemistry, December 1994, American Chemical Society (ACS)

    Prof Stefano Manfredini

  107. Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines

    Article • Journal of Medicinal Chemistry, December 1994, American Chemical Society (ACS)

    Prof Stefano Manfredini

  108. Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c] pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c] pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists.

    Article • Bioorganic & Medicinal Chemistry Letters, November 1994, Elsevier

    Prof Stefano Manfredini

  109. A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates

    Article • Tetrahedron Letters, August 1994, Elsevier

    Prof Stefano Manfredini

  110. Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain

    Article • Journal of Medicinal Chemistry, July 1994, American Chemical Society (ACS)

    Prof Stefano Manfredini

  111. A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives

    Article • Journal of the Chemical Society Chemical Communications, January 1994, Royal Society of Chemistry

    Prof Stefano Manfredini

  112. Cholinergic agents structurally related to furtrethonium. 1

    Article • European Journal of Medicinal Chemistry, January 1994, Elsevier

    Prof Stefano Manfredini

  113. Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs)

    Article • Bioorganic & Medicinal Chemistry Letters, December 1993, Elsevier

    Prof Stefano Manfredini

  114. An unusual trimethylsilyltriflate catalyzed transformation of 6-[3-aryl-2-hydroxypropyl]-4,5-dihydro-3(2-pyridazinones into 3-(1-naphthyl)propionic acid esters

    Article • Tetrahedron Letters, June 1993, Elsevier

    Prof Stefano Manfredini

  115. Facile access to 2′-O-acyl prodrugs of 1- (β-d-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′-triesters1

    Article • Tetrahedron Letters, May 1993, Elsevier

    Prof Stefano Manfredini

  116. An Efficient Synthesis of 4-Oxo-2,5-hexadienoates via Δ 2 -Isoxazoline Intermediates

    Article • Synthesis, January 1993, Thieme Publishing Group

    Prof Stefano Manfredini

  117. Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain.

    Article • Journal of Medicinal Chemistry, May 1992, American Chemical Society (ACS)

    Prof Stefano Manfredini

  118. Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast

    Article • Tetrahedron Letters, May 1992, Elsevier

    Prof Stefano Manfredini

  119. Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides

    Article • Journal of Medicinal Chemistry, March 1992, American Chemical Society (ACS)

    Prof Stefano Manfredini

  120. Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates

    Article • Journal of Medicinal Chemistry, November 1991, American Chemical Society (ACS)

    Prof Stefano Manfredini

  121. Nucleic acid related compounds. 65. New syntheses of 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-iodovinyl)uracil (IVAraU) from vinylsilane precursors. Radioiodine uptake as a marker for thymidine kinase herpes viral infections

    Article • Journal of Medicinal Chemistry, July 1991, American Chemical Society (ACS)

    Prof Stefano Manfredini

  122. Ha-ras-1 Transfected Cells: Induction to Differentiation by Natural and Synthetic Retinoids

    Article • January 1991, Springer Science + Business Media

    Professor Claudio Nastruzzi, Prof Stefano Manfredini

  123. A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin.

    Article • Tetrahedron Letters, January 1991, Elsevier

    Prof Stefano Manfredini

  124. Synthesys of Isoxazole and Isoxazoline Derivatives of Retinoids: Effects on Growth and Differentiation of Tumor Cells

    Article • January 1991, Springer Science + Business Media

    Prof Stefano Manfredini

  125. Synthèse de quelques dérivés isoxazoliques analogues des rétinoides. Effects biologiques vis-à-vis des cellules tumorales

    Article • European Journal of Medicinal Chemistry, April 1990, Elsevier

    Prof Stefano Manfredini

  126. Conversion of vinylsilanes to vinyl halides with xenon difluoride and metal halides. A versatile new route to 5-(2-halovinyl)pyrimidine nucleosides

    Article • Tetrahedron Letters, January 1990, Elsevier

    Prof Stefano Manfredini

  127. Synthesis and cytostatic activity of geiparvarin analogs

    Article • Journal of Medicinal Chemistry, February 1989, American Chemical Society (ACS)

    Prof Stefano Manfredini

  128. 3,4-Bismethylenecyclopentanone ethylene ketal: A useful diene for[6.5]ring systems: Application to a formal synthesis of gibberellic acid

    Article • Tetrahedron, January 1989, Elsevier

    Prof Stefano Manfredini

  129. A [3+2] nitrile oxide cycloaddition approach to retinoids

    Article • Tetrahedron Letters, January 1988, Elsevier

    Prof Stefano Manfredini

  130. A convenient synthesis of λ-oxo-acrylates

    Article • Tetrahedron Letters, January 1988, Elsevier

    Prof Stefano Manfredini

  131. Isoxazoles-mediated synthesis of geiparvarin and dihydrogeiparvarin

    Article • Tetrahedron, January 1988, Elsevier

    Prof Stefano Manfredini

  132. Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene

    Article • Tetrahedron, January 1988, Elsevier

    Prof Stefano Manfredini

  133. Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H) furanones and 3(2H) furanimines

    Article • Tetrahedron, January 1987, Elsevier

    Prof Stefano Manfredini

  134. Synthesis and Interaction of 5-(Substituted-phenyl)-3-methy1-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(7H)-ones with Benzodiazepine Receptors in Rat Cerebral Cortex

    Article • Journal of Medicinal Chemistry, May 1985, American Chemical Society (ACS)

    Prof Stefano Manfredini

  135. A new nitrile oxide based synthesis of the antitumor agent geiparvarin

    Article • Tetrahedron Letters, January 1985, Elsevier

    Prof Stefano Manfredini

  136. Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-.beta.-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyrimidin-7-ones

    Article • Journal of Medicinal Chemistry, August 1984, American Chemical Society (ACS)

    Prof Stefano Manfredini

  137. Ethyl 5-substituted-3-isoxazolecarboxylates as starting materials for a convenient route to 3(2H)furanones and 3(2H)iminofuranes.

    Article • Tetrahedron Letters, January 1984, Elsevier

    Prof Stefano Manfredini

  138. Preparation of 3,4-Dihydroxy-1-benzeneethanol: A Reinvestigation

    Article • European Journal of Organic Chemistry, April 1983, Wiley

    Prof Stefano Manfredini