What is it about?

There is need for rapid methods for the preparation of new heterocyclic compounds with biomedical properties. We describe a new reaction that allows the preparation of complex heterocyclic compounds with interesting fluorescent properties, as well as antiviral and potential anticancer properties.

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Why is it important?

The methodology developed allows the selective synthesis of a large number of complex heterocyclic compounds starting with simple compounds. The methodology uses a new reaction in the field of multicomponent reactions that allows to control the reactivity by the preferential generation of intermediates which are less reactive than the initial substrates. The properties of new compounds were analyzed finding new compounds that are bright fluorescent emitters, compounds with antiviral properties and compounds that bind selectively in certain areas of the DNA.


This was the result of an excelent collaboration of several groups making a true interdisciplinary study.

Ramon Eritja

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This page is a summary of: Multiple Multicomponent Reactions: Unexplored Substrates, Selective Processes, and Versatile Chemotypes in Biomedicine, Chemistry - A European Journal, August 2018, Wiley, DOI: 10.1002/chem.201802877.
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