What is it about?

The extracellular matrix (ECM) is a macromolecular network, which can provide biochemical and structural support for cell adhesion and formation. It regulates cell behavior by influencing biochemical and physical cues. It is a dynamic structure whose components are modified, degraded or deposited during connective tissue development, giving tissues strength and structural integrity.

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Why is it important?

The physical properties of the natural ECM environment control the design of naturally or synthetically derived biomaterials to guide cell function in tissue engineering. Tissue engineering is an important field that explores physical cues of ECM to produce new viable tissue for medical applications, such as in organ transplant and organ recovery. Understanding how the ECM exerts physical effects on cell behavior, when cells are seeded in synthetic ECM scaffolds, is of utmost importance.


Herein, we review recent findings in this area that report on cell behaviors in a variety of ECMs with different physical properties i.e ., topology, geometry, dimensionality, stiffness and tension.

Dr. Sitansu Sekhar Nanda
Myongji University

Read the Original

This page is a summary of: Mechano‐physical Cues in Extracellular Matrix Regulation of Cell Behaviors, ChemBioChem, December 2019, Wiley,
DOI: 10.1002/cbic.201900686.
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