What is it about?
Bergenin, 4-O-methyl gallic acid glucoside, is a bioactive compound in various plants belonging to different families. The present work compiles scattered information on pharmacology, structure-activity relationship and nanotechnological aspects of bergenin, collected from various electronic databases such as Sci Finder, PubMed, Google Scholar, etc. Bergenin has been reported to exhibit hepatoprotective, anti-inflammatory, anticancer, neuroprotective, antiviral, and antimicrobial activities. Molecular docking studies have shown that isocoumarin pharmacophore of bergenin is essential for its bioactivities. Bergenin holds a great potential to be used as a lead molecule and also as a therapeutic agent for the development of more efficacious and safer semisynthetic derivatives. Nanotechnological concepts can be employed to overcome the poor bioavailability of bergenin. Finally, it is concluded that bergenin can emerge as clinically potential medicine in modern therapeutics.
Featured Image
Photo by Henry Be on Unsplash
Why is it important?
Bergenin can emerge as clinically potential medicine in modern therapeutics.
Perspectives
Bergenin holds a great potential to be used as a lead molecule and also as a therapeutic agent for the development of more efficacious and safer semisynthetic derivatives. Nanotechnological concepts can be employed to overcome the poor bioavailability of bergenin.
Dr. Dinesh Kumar
Read the Original
This page is a summary of: Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives, Current Topics in Medicinal Chemistry, February 2022, Bentham Science Publishers,
DOI: 10.2174/1568026621666211015092654.
You can read the full text:
Contributors
The following have contributed to this page
