What is it about?
The analysis of the spatial and temporal organization of biocatalysis in cellular and subcellular systems provides valuable clues for resource‐ and energy‐efficient synthetic routes to natural metabolites. At the same time metabolites are needed for these analyses and the synthesis of metabolites is experiencing a renaissance.
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Why is it important?
Although the analysis, identification, characterization and synthesis of metabolites has a long history of milestone discoveries, it continues to be of great interest in the search for novel biological activities, metabolic pathways, diagnostic and therapeutic applications. Biologically active metabolites benefit from advantages in diffusion and transport for various interactions with proteins and nucleic acids and regulatory events.
Perspectives
This renaissance of metabolite synthesis will be beneficial not only to the discovery of novel enzyme functions and novel pathways, but also to contribute to better investigate the molecular mechanism of inherited and acquired diseases, such as inborn errors of metabolism and cancer.
Prof. Dr. Roland Wohlgemuth
Lodz University of Technology
Read the Original
This page is a summary of: Horizons of Systems Biocatalysis and Renaissance of Metabolite Synthesis, Biotechnology Journal, May 2018, Wiley,
DOI: 10.1002/biot.201700620.
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