A Combined Atomic Force Microscopy and Computational Approach for the Structural Elucidation of Breitfussin A and B: Highly Modified Halogenated Dipeptides fromThuiaria breitfussi

Kine Ø. Hanssen, Bruno Schuler, Antony J. Williams, Taye B. Demissie, Espen Hansen, Jeanette H. Andersen, Johan Svenson, Kirill Blinov, Michal Repisky, Fabian Mohn, Gerhard Meyer, John-Sigurd Svendsen, Kenneth Ruud, Mikhail Elyashberg, Leo Gross, Marcel Jaspars, Johan Isaksson
  • Angewandte Chemie International Edition, October 2012, Wiley
  • DOI: 10.1002/anie.201203960

Applying Atomic Force Microscopy and Computer Assisted Structure Elucidation in Tandem

What is it about?

This publication reports on the combined application of single molecule atomic force microscopy and computer-assisted structure elucidation to elucidate the chemical structures of a complex marine natural product.

Why is it important?

The great promise of single molecule atomic force microscopy is excellent but there are certain conditions where it is still limited in its resolving power. Nuclear Magnetic Resonance combined with computer-assisted structure elucidation is a very powerful combination when applied together and can support the data extracted using AFM.

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The following have contributed to this page: Dr Antony John Williams and Kirill Blinov