What is it about?

The chapter presents the epidemiology, pathophysiology, clinical features, radiographic features and treatment for low-grade and anaplastic oligodendrogliomas.

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Why is it important?

The presence of histopathological features of both oligodendroglial and astrocytic morphology is classified as oligoastrocytomas or anaplastic oligoastrocytomas. Despite recent advances in understanding of the molecular genetic features of OD and therapeutic advances that have demonstrated clear benefit from radio-chemotherapy as initial treatment, OD remains an incurable and fatal disease. Oligodendroglial neoplasms harbor distinct and exclusive molecular genetic derangements and these biomarkers have prognostic and therapeutic significance.


The clinical presentation of a patient with an oligodendroglial neoplasm is influenced by tumour location and rapidity of growth. The management of OD depends on grade and location. Options for low-grade OD include surgery, radiotherapy, and chemotherapy. Despite remarkable developments in understanding of the molecular biology and ability to treat these tumours, they remain ultimately fatal diseases.

Dr Catherine Maurice
University of Toronto

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This page is a summary of: Low-grade and anaplastic oligodendrogliomas, April 2016, Wiley, DOI: 10.1002/9781118777329.ch137.
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