What is it about?

Non-coding RNAs can regulate gene expression, and their dysregulation can result in the progression of various diseases. This review summarises the latest findings of non-coding RNAs' role in disease pathogenesis, focusing on osteoarthritis. In addition, utilisation of ncRNA in clinical practice is mentioned.

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Why is it important?

Understanding the molecular mechanism of non-coding RNAs in diseases could potentially open the door for their use as biomarkers or targeted therapeutics. Especially in osteoarthritis, no treatment has been developed yet, and ncRNAs can be the right way in the future.


With the technical advances, there is a growing number of studies focused on various types of non-coding RNAs. This review summarises the theoretical background of each ncRNA and connects it with the recent studies.

Aneta Pekáčová
Institute of Rheumatology

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This page is a summary of: Non‐coding RNAs in diseases with a focus on osteoarthritis, Wiley Interdisciplinary Reviews - RNA, September 2022, Wiley,
DOI: 10.1002/wrna.1756.
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