What is it about?

It may be concluded that vitamin K1 decreases the propensity of α- syn aggregation in the presence of SWCNTs and induction of cytotoxicity.

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Why is it important?

understanding the role of CNTs in α-syn aggregation and introduction of some protective agents is crucial for the development of new therapies, which this study examines the protective effect of vitamin K1 against α-syn aggregation and their associated cytotoxicity in SHSY5Y cell model induced by SWCNT


It is very important article ,Because vitamin K1 was revealed to considerably prevent the formation of amorphous aggregation of α-syn in the presence of SWCNT and its relevant cytotoxicity. Our data suggested that vitamin K1 binds to α-syn monomer and mask the binding site of SWCNT. Furthermore, cytotoxicity experiments revealed that the amorphous aggregates formed by SWCNT in the absence of vitamin K1 are more toxic compared to non-aggregated species produced in thepresence of vitamin K1. The data obtained may provide in depth insight into probable mechanisms of aggregation inhibition by vitamins and an applicable suggestion about designing unique inhibitors.

professor asaad bader Alasady
Al Iraqia University

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This page is a summary of: Vitamin K1 As A Potential Molecule For Reducing Single-Walled Carbon Nanotubes-Stimulated α-Synuclein Structural Changes And Cytotoxicity, International Journal of Nanomedicine, October 2019, Taylor & Francis, DOI: 10.2147/ijn.s223182.
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