What is it about?

Machine perfusion of the liver is a promising tool to expand the organ pool to attend to the increased demand for transplantation. Its utilisation for allowing the safe transplantation of an extended criteria donor allograft after brain death into an acute-on-chronic liver failure (ACLF)-2 patient with high MELD-Na

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Why is it important?

ACLF is a major cause of mortality in patients with cirrhosis, and the time window for transplantation in these critically ill patients is narrow.


Machine perfusion of the liver may prove to be a safe tool to expand the donor organ pool and expedite transplantation in the ACLF setting.

Yuri Boteon
University of Birmingham

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This page is a summary of: Hypothermic oxygenated machine perfusion as a tool to facilitate liver transplantation in the acute‐on‐chronic liver failure scenario, Liver Transplantation, June 2022, Wiley,
DOI: 10.1002/lt.26513.
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