What is it about?

IRE1 is an important central regulator of unfolded protein response (UPR) in the endoplasmic reticulum (ER) because of its ability to regulate cell fate as a function of stress sensing. This review provides updated data about the role IRE1 plays in chondrocytes.

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Why is it important?

Deep insights into the function of IRE-1 in chondrocytes and new suggestions to prevent chondrocyte death


This publication introduces a new view to the clinical researchers to target IRE-1 for preventing chondrocyte apoptosis and cartilage loss

Dr Murad Alahdal
Johns Hopkins University

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This page is a summary of: IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis, Journal of Cellular Physiology, July 2021, Wiley,
DOI: 10.1002/jcp.30537.
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