What is it about?

Tight junctions adjusts their paracellular permeability and selectivity to conditions imposed by the environment. We studied how a substance from the environment, the epidermal growth factor, activates the transcription factor STAT3 to change the molecular composition of tight junctions and make them tighter.

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Why is it important?

We have discovered a new signaling pathway for the regulation of tight junctions involving the transcription factor STAT3.

Perspectives

It is always fun to find new avenues.

Dr Rubén G. Contreras
Cinvestav

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This page is a summary of: EGF Regulates Claudin-2 and -4 Expression Through Src and STAT3 in MDCK Cells, Journal of Cellular Physiology, September 2014, Wiley, DOI: 10.1002/jcp.24687.
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