What is it about?

Breast cancer is one of the most common gynecological cancers in women; it is considered the fourth leading cause of death among other cancers. Despite new methods and drugs to treat breast cancer and the good results obtained with them, there are a variety of chemicals and natural products that have not yet been studied and tested as anticancer agents.

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Why is it important?

- The bis-structured Schiff base is considered a new compound with prominent anti-cancer potential. - For the first time, the apoptotic, cytotoxic, and genotoxic properties of bis-structured Schiff base were studied in breast cancer cell lines at various concentrations.

Perspectives

- The current original study was performed using standard apoptotic and cytotoxic assays, such as single-cell gel electrophoresis assay (Comet assay), DNA fragmentation ladder, acridine orange assay for DNA damage, and ELISA to measure apoptosis.

Yasin TÜLÜCE
Van Yüzüncü Yıl University

Read the Original

This page is a summary of: The effect of a bis‐structured Schiff base on apoptosis, cytotoxicity, and DNA damage of breast cancer cells, Journal of Biochemical and Molecular Toxicology, June 2022, Wiley,
DOI: 10.1002/jbt.23148.
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