What is it about?

Breast cancer is one of the most common gynecological cancers in women; it is considered the fourth leading cause of death among other cancers. Despite new methods and drugs to treat breast cancer and the good results obtained with them, there are a variety of chemicals and natural products that have not yet been studied and tested as anticancer agents.

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Why is it important?

- The bis-structured Schiff base is considered a new compound with prominent anti-cancer potential. - For the first time, the apoptotic, cytotoxic, and genotoxic properties of bis-structured Schiff base were studied in breast cancer cell lines at various concentrations.


- The current original study was performed using standard apoptotic and cytotoxic assays, such as single-cell gel electrophoresis assay (Comet assay), DNA fragmentation ladder, acridine orange assay for DNA damage, and ELISA to measure apoptosis.

Van Yüzüncü Yıl University

Read the Original

This page is a summary of: The effect of a bis‐structured Schiff base on apoptosis, cytotoxicity, and DNA damage of breast cancer cells, Journal of Biochemical and Molecular Toxicology, June 2022, Wiley,
DOI: 10.1002/jbt.23148.
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