What is it about?
• Ovarian cancer cells show selectivity to the adipocyte-rich tissues such as omentum upon dissemination, and proliferates there at a rate higher than that of the primary lesion, however, there are still a lot of unclear points about the detailed mechanism. • Ovarian cancer cells promote the dedifferentiation process of omental adipocytes through Wnt signaling and induce omental adipocyte-derived fibroblasts (O-ADF). • O-ADFs thus generated promote the growth and migration of ovarian cancer cells and contributes to tumor progression at peritoneal dissemination site.
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This page is a summary of: Pro‐tumoral behavior of omental adipocyte‐derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer, International Journal of Cancer, September 2021, Wiley, DOI: 10.1002/ijc.33770.
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