What is it about?

Monitoring the behavior of multiple zebrafish larvae on-demand and at the same time is important in biological investigations. A quadruple-fish electro-fluidic device for behavioral phenotyping of zebrafish larvae and investigation of dopaminergic pathways involved in response to electricity is provided in this paper. This methodology can be used in many assays involving zebrafish as a model organism for disease studies and drug screening.

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Why is it important?

The demonstrated techniques and design will enable faster and more efficient screening, holding potential in the fields of phenotypic neurobehavioral research for drug discovery and toxicology.

Perspectives

The demonstrated techniques and design will enable faster and more efficient screening, holding potential in the fields of phenotypic neurobehavioral research for drug discovery and toxicology. Further modifications to the device, dependent on the microscopy capabilities such as the FOV, could increase the number of fish tested simultaneously to further reduce the testing time and enhance the throughput of behavioral assays with the proposed technology. Additional features such as on-chip chemical exposure could likewise expand the applications and range of the design presented.

Arezoo Khalili
York University

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This page is a summary of: Designing microfluidic devices for behavioral screening of multiple zebrafish larvae, Biotechnology Journal, November 2021, Wiley, DOI: 10.1002/biot.202100076.
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