What is it about?
"Nanosizing" drug crystals is an established approach to improve the performance of orally-delivered hydrophobic drugs by decreasing the size of drug crystals to the nano-scale. However, conventional nanosizing methods are energy-intensive and difficult to optimize. Additionally, combination drug products, which have multiple drugs in the same pill, have many clinical benefits, but are difficult to manufacture. Here, we demonstrate a versatile approach to generate and stabilize drug nanocrystals inside hydrogels. We use two orthogonal gelations to make core-shell hydrogels which can structure distinct drugs in each layer. Our approach enables independently controllable drug loading and release in each layer, suggesting a potentially scalable route for manufacturing combination products of hydrophobic drugs.
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Why is it important?
We have shown that generating drug nanocrystals from nanoemulsions is a viable and potentially scalable approach. This "bottom-up" route for making drug nanocrystals could represent a paradigm shift from the conventional "top-down" routes used in industry. Our work also demonstrates a new way to make combination drug products that can be adapted for a given drug combination. Finally, our use of orthogonal gelations represents a new way that functional core-shell hydrogels could be manufactured for other applications.
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This page is a summary of: Orthogonal Gelations to Synthesize Core‐Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery, Advanced Healthcare Materials, July 2023, Wiley, DOI: 10.1002/adhm.202301667.
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