What is it about?
In this paper, we found Absent in Melanoma 2 (Aim2) protein plays very important role in the development of Systemic lupus erythematosus in an optimal Ube2i-mediated sumoylation-based suppression of type I IFN generation and development of SLE. As such, the Aim2–Ube2i axis can thus be a novel target for intervention in SLE.
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Why is it important?
Our work elucidates an important and novel mechanism for Aim2-mediated inhibition of type I IFN expression in the development and pathogenesis of lupus, which points to the Aim2-Ube2i complex as a new therapeutic target in SLE.
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This page is a summary of: Aim2
Couples With
Ube2i
for Sumoylation‐Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Arthritis & Rheumatology, July 2021, Wiley,
DOI: 10.1002/art.41677.
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