What is it about?
In this paper, we found Absent in Melanoma 2 (Aim2) protein plays very important role in the development of Systemic lupus erythematosus in an optimal Ube2i-mediated sumoylation-based suppression of type I IFN generation and development of SLE. As such, the Aim2–Ube2i axis can thus be a novel target for intervention in SLE.
Photo by Intricate Explorer on Unsplash
Why is it important?
Our work elucidates an important and novel mechanism for Aim2-mediated inhibition of type I IFN expression in the development and pathogenesis of lupus, which points to the Aim2-Ube2i complex as a new therapeutic target in SLE.
Read the Original
This page is a summary of: Aim2
for Sumoylation‐Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Arthritis & Rheumatology, July 2021, Wiley,
You can read the full text:
The following have contributed to this page