What is it about?

In this paper, we found Absent in Melanoma 2 (Aim2) protein plays very important role in the development of Systemic lupus erythematosus in an optimal Ube2i-mediated sumoylation-based suppression of type I IFN generation and development of SLE. As such, the Aim2–Ube2i axis can thus be a novel target for intervention in SLE.

Featured Image

Why is it important?

Our work elucidates an important and novel mechanism for Aim2-mediated inhibition of type I IFN expression in the development and pathogenesis of lupus, which points to the Aim2-Ube2i complex as a new therapeutic target in SLE.


Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. ch. Moreover, I think it is a great work for us to find novel mechanism by how AIM2 involving SLE. Hope you find this article thought-provoking.

ailing lu lu
The Feinstein Insititute for Medical Research

Read the Original

This page is a summary of: Aim2 Couples With Ube2i for Sumoylation‐Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Arthritis & Rheumatology, July 2021, Wiley,
DOI: 10.1002/art.41677.
You can read the full text:




The following have contributed to this page