What is it about?

Chitosan derivatives as raw material preparation of N - 2 - HACC WenMinShui gel, wound healing with SD rats experiment evaluation of their effects on wound healing, N - 2 - HACC hydrogel as a wound dressing, with good wound healing effect has good biocompatibility, biodegradability, non-toxic, excellent antibacterial properties and barrier effect in the process of wound.

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Why is it important?

This research synthesized of temperature sensitive N - 2 - HACC hydrogel gel forming time and stable, with good water-holding capacity, can be very beneficial to accelerate wound healing environment and security, can promote cell proliferation, for its used as wound dressings, accelerate wound healing provided a guarantee, can inhibit the secretion of inflammatory cytokines, reduce wound inflammation. At the same time, in the hyperplasia stage of wound healing, hydrogel can regulate the expression of growth factors TGF-β1 and EGF, promote the secretion of VEGF, accelerate the formation of new blood vessels and granulation tissue and the wound healing rate.


It is a great pleasure to write this article, and I hope this article can provide certain theoretical data and reference for the field of wound repair.

Hongli Wang

Read the Original

This page is a summary of: N‐2‐hydroxypropyl trimethyl ammonium chloride chitosan‐glycerol complex temperature‐sensitive hydrogel for wound dressing, Journal of Applied Polymer Science, September 2022, Wiley, DOI: 10.1002/app.53112.
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