What is it about?

We investigated how lifestyle-related factors such as metabolic/vascular risk, physical and/or cognitive activity influence amyloid pathology and cognition and whether associations differ between sexes. Our population of interest were healthy aging persons with some of them exhibiting early cognitive impairment. We used positron emission tomography (PET) scan to measure each individuals brain amyloid pathology.

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Why is it important?

The study indicates that the effects of some but not all lifestyle-related factors on brain amyloid burden and cognitive performance differ between men and women. Higher physical activity was associated with lower amyloid burden in men and higher metabolic/vascular risk tended to correlated with higher amyloid burden in women whereas in men it was associated with lower cognitive performance. Cognitive activity seems to be equally importnat for both men and women and was associated with better cognitive performance.


Stratification of cohorts into appropriate subgroups is important to address the complexity of AD and other chronic diseases.

Dario Bachmann
Institute for Regenerative Medicine

Read the Original

This page is a summary of: Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women, Annals of Neurology, June 2022, Wiley,
DOI: 10.1002/ana.26417.
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