What is it about?

EWG is electron-withdrawing-group that will lower the electron density of the compound,thus might allowing a following nucleophilic reaction. Therefore,when the EWG is settled on the aromatics,a desirable nucleophilic addition might occur,that will break the aromaticity to form a dearomatized cyclic structures. Therefore such a strategy is a useful tool to access the complicated structures.

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Why is it important?

This strategy provides an alternative powerfull approach to access the complicated cyclic structures,which would be an important or potential lead compound or useful mmaterial


This review would inspire the readers to find more straight forward approach to realize the dearomatization reaction.

Xiao-Long He He
Xihua University

Read the Original

This page is a summary of: Recent Progress of Electron‐Withdrawing‐Group‐Tethered Arenes Involved Asymmetric Nucleophilic Aromatic Functionalizations, Advanced Synthesis & Catalysis, October 2022, Wiley,
DOI: 10.1002/adsc.202200835.
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