All Stories

  1. Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus

    Article • Antiviral Research, October 2018, Elsevier

    Dr David Robert McGivern

  2. An Efficient, Large-Scale Survey of Hepatitis C Viremia in the Democratic Republic of the Congo Using Dried Blood Spots

    Article • Clinical Infectious Diseases, October 2017, Oxford University Press (OUP)

    Dr David Robert McGivern

  3. NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR

    Article • Nature Immunology, October 2017, Springer Science + Business Media

    Dr David Robert McGivern

  4. NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

    Article • PLoS Pathogens, June 2017, PLOS

    Dr David Robert McGivern

  5. Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

    Article • mBio, April 2017, ASM Journals

    Dr David Robert McGivern

  6. Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation

    Article • Scientific Reports, December 2016, Springer Science + Business Media

    Dr David Robert McGivern

  7. MAVS-dependent host species range and pathogenicity of human hepatitis A virus

    Article • Science, September 2016, American Association for the Advancement of Science

    Dr David Robert McGivern

  8. Mechanism of Action of Direct-Acting Antivirals: New Insights into the HCV Life Cycle

    Article • January 2016, Springer Science + Business Media

    Dr David Robert McGivern

  9. How do persistent infections with hepatitis C virus cause liver cancer?

    Article • Current Opinion in Virology, October 2015, Elsevier

    Dr David Robert McGivern

  10. Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production

    Article • PLoS ONE, August 2015, PLOS

    Dr David Robert McGivern

  11. Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle

    Article • Journal of Virology, March 2015, ASM Journals

    Dr David Robert McGivern

  12. miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation

    Article • Cell Host & Microbe, February 2015, Elsevier

    Dr David Robert McGivern

  13. Kinetic Analyses Reveal Potent and Early Blockade of Hepatitis C Virus Assembly by NS5A Inhibitors

    Article • Gastroenterology, August 2014, Elsevier

    Dr David Robert McGivern

  14. Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

    Article • Nature Reports Stem Cells, July 2014, Springer Science + Business Media

    Dr David Robert McGivern

  15. Mechanisms of hepatocarcinogenesis in chronic hepatitis C

    Article • Hepatic Oncology, June 2014, Future Medicine

    Dr David Robert McGivern

  16. HEP DART 2013: frontiers in drug development for viral hepatitis. Big Island, Hawaii, USA - December 8-12, 2013

    Article • Drugs of the Future, January 2014, Prous Science

    Dr David Robert McGivern

  17. Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells

    Article • PLoS Pathogens, May 2013, PLOS

    Dr David Robert McGivern

  18. Liver Injury and Disease Pathogenesis in Chronic Hepatitis C

    Article • January 2013, Springer Science + Business Media

    Dr David Robert McGivern, Ralf Bartenschlager

  19. Competing and noncompeting activities of miR-122 and the 5′ exonuclease Xrn1 in regulation of hepatitis C virus replication

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Dr David Robert McGivern

  20. Is Hepatitis C Virus Carcinogenic?

    Article • Gastroenterology, May 2012, Elsevier

    Dr David Robert McGivern

  21. Model Systems for Hepatitis C Research: The Cup Half Empty?

    Article • Gastroenterology, September 2011, Elsevier

    Dr David Robert McGivern

  22. Hepatitis C Virus Infection Causes Cell Cycle Arrest at the Level of Initiation of Mitosis

    Article • Journal of Virology, June 2011, ASM Journals

    Dr David Robert McGivern

  23. Protease Inhibitor–Resistant Hepatitis C Virus Mutants With Reduced Fitness From Impaired Production of Infectious Virus

    Article • Gastroenterology, February 2011, Elsevier

    Dr David Robert McGivern

  24. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

    Article • Oncogene, January 2011, Springer Science + Business Media

    Dr David Robert McGivern

  25. Roles of the respiratory syncytial virus trailer region: Effects of mutations on genome production and stress granule formation

    Article • Virology, October 2010, Elsevier

    Dr David Robert McGivern

  26. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion

    Article • Proceedings of the National Academy of Sciences, May 2010, Proceedings of the National Academy of Sciences

    Dr David Robert McGivern

  27. Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma

    Article • January 2010, Springer Science + Business Media

    Dr David Robert McGivern

  28. Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

    Article • Journal of General Virology, September 2009, Society for General Microbiology

    Dr David Robert McGivern

  29. Impaired Replication of Hepatitis C Virus Containing Mutations in a Conserved NS5B Retinoblastoma Protein-Binding Motif

    Article • Journal of Virology, May 2009, ASM Journals

    Dr David Robert McGivern

  30. Tumor Suppressors, Chromosomal Instability, and Hepatitis C Virus–Associated Liver Cancer

    Article • Annual Review of Pathology Mechanisms of Disease, February 2009, Annual Reviews

    Dr David Robert McGivern

  31. Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein

    Article • PLoS Pathogens, January 2007, PLOS

    Dr David Robert McGivern

  32. Unravelling the complexities of respiratory syncytial virus RNA synthesis

    Article • Journal of General Virology, July 2006, Society for General Microbiology

    Dr David Robert McGivern

  33. An intact RBR-binding motif is not required for infectivity of Maize streak virus in cereals, but is required for invasion of mesophyll cells

    Article • Journal of General Virology, March 2005, Society for General Microbiology

    Dr David Robert McGivern

  34. A three-nucleotide mutation altering the Maize streak virus Rep pRBR-interaction motif reduces symptom severity in maize and partially reverts at high frequency without restoring pRBR-Rep binding

    Article • Journal of General Virology, March 2005, Society for General Microbiology

    Dr David Robert McGivern

  35. Identification of Internal Sequences in the 3′ Leader Region of Human Respiratory Syncytial Virus That Enhance Transcription and Confer Replication Processivity

    Article • Journal of Virology, February 2005, ASM Journals

    Dr David Robert McGivern