All Stories

  1. The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression

    Article • Molecular and Cellular Biology, July 2013, ASM Journals

    Professor Akira Kobayashi

  2. Dual Regulation of the Transcriptional Activity of Nrf1 by  -TrCP- and Hrd1-Dependent Degradation Mechanisms

    Article • Molecular and Cellular Biology, September 2011, ASM Journals

    Professor Akira Kobayashi

  3. The Keap1–Nrf2 system as an in vivo sensor for electrophiles

    Article • Nitric Oxide, August 2011, Elsevier

    Professor Akira Kobayashi

  4. Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

    Article • Genes to Cells, May 2011, Wiley

    Professor Akira Kobayashi, Dr Yosuke Hirotsu, Professor Yoshiro Saito

  5. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Article • Nature Cell Biology, February 2010, Springer Science + Business Media

    Professor Akira Kobayashi

  6. Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

    Article • Journal of Biological Chemistry, September 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Akira Kobayashi

  7. Keap1 Regulates the Constitutive Expression of GST A1 during Differentiation of Caco-2 Cells †

    Article • Biochemistry, June 2008, American Chemical Society (ACS)

    Professor Akira Kobayashi

  8. Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

    Article • Journal of Synchrotron Radiation, April 2008, International Union of Crystallography

    Professor Akira Kobayashi

  9. Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

    Article • Cancer Research, March 2008, American Association for Cancer Research (AACR)

    Professor Akira Kobayashi

  10. Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

    Article • Journal of Neurochemistry, February 2008, Wiley

    Professor Akira Kobayashi

  11. Molecular Evolution of Keap1

    Article • Journal of Biological Chemistry, December 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Akira Kobayashi

  12. Subcellular localization and cytoplasmic complex status of endogenous Keap1

    Article • Genes to Cells, October 2007, Wiley

    Professor Akira Kobayashi

  13. Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer

    Article • Molecular Cell, March 2006, Elsevier

    Professor Akira Kobayashi

  14. Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

    Article • Molecular and Cellular Biology, January 2006, ASM Journals

    Professor Akira Kobayashi

  15. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

    Article • Biological Chemistry, January 2006, De Gruyter

    Professor Akira Kobayashi

  16. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity

    Article • Biochemical and Biophysical Research Communications, January 2006, Elsevier

    Professor Akira Kobayashi

  17. Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

    Article • Advances in Enzyme Regulation, January 2006, Elsevier

    Professor Akira Kobayashi

  18. Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

    Article • Antioxidants & Redox Signaling, March 2005, Mary Ann Liebert Inc

    Professor Akira Kobayashi

  19. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

    Article • Archives of Biochemistry and Biophysics, January 2005, Elsevier

    Professor Akira Kobayashi

  20. Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

    Article • Molecular and Cellular Biology, August 2004, ASM Journals

    Professor Akira Kobayashi

  21. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

    Article • Proceedings of the National Academy of Sciences, February 2004, Proceedings of the National Academy of Sciences

    Professor Akira Kobayashi

  22. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

    Article • Proceedings of the National Academy of Sciences, February 2004, Proceedings of the National Academy of Sciences

    Professor Akira Kobayashi

  23. Unique Function of the Nrf2–Keap1 Pathway in the Inducible Expression of Antioxidant and Detoxifying Enzymes

    Article • January 2004, Elsevier

    Professor Akira Kobayashi