All Stories

  1. Analysis of ordered composite endpoints
  2. Interim Monitoring for Futility in Clinical Trials With Two Co-Primary Endpoints Using Prediction
  3. Antenatal Therapy for Fetal Supraventricular Tachyarrhythmias
  4. Association of CYP2C19 Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke
  5. Development and Validation of an Ischemic and Bleeding Risk Evaluation Tool in East Asian Patients Receiving Percutaneous Coronary Intervention
  6. Evaluating the safety and technical effectiveness of a newly developed intravascular ’flow isolator' stent for the treatment of intracranial aneurysms: study protocol for a first-in-human single-arm multiple-site clinical trial in Japan
  7. Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes
  8. Effects of Teneligliptin on the Progressive Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus in Open-Label, Marker-Stratified Randomized, Parallel-Group Comparison, Standard Treatment-Controlled Multicenter Trial (TOPLEV...
  9. Recombinant thrombomodulin for acute exacerbation in idiopathic interstitial pneumonias
  10. Rivaroxaban administration after acute ischemic stroke: The RELAXED study
  11. Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response
  12. The Survival Benefit of a Novel Trauma Workflow that Includes Immediate Whole-body Computed Tomography, Surgery, and Interventional Radiology, All in One Trauma Resuscitation Room
  13. External Validation of the Two Newly Proposed Criteria for Assessing Coagulopathy in Sepsis
  14. Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design
  15. Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)
  16. Cardiovascular Outcomes in Patients With Previous Myocardial Infarction and Mild Diabetes Mellitus Following Treatment With Pioglitazone
  17. Effect of the Hybrid Emergency Room System on Functional Outcome in Patients with Severe Traumatic Brain Injury
  18. Japanese Antibacterial Drug Management for Cardiac Sarcoidosis (J-ACNES): A multicenter, open-label, randomized, controlled study
  19. Rationale and Design of the Multicenter Trial on Japan Working Group on the Effects of Angiotensin Receptor Blockers Selection (Azilsartan vs. Candesartan) on Diastolic Function in the Patients Suffering from Heart Failure with Preserved Ejection Fract...
  20. In Reply to “ Streptococcus mutans with Collagen-Binding Protein: From Oral Cavity to Brain”
  21. Assessment of Safety and Effectiveness of the Extracorporeal Continuous-Flow Ventricular Assist Device (BR16010) Use as a Bridge-to-Decision Therapy for Severe Heart Failure or Refractory Cardiogenic Shock: Study Protocol for Single-Arm Non-randomized,...
  22. A Potential New Risk Factor for Stroke: Streptococcus Mutans With Collagen-Binding Protein
  23. Sustained Effectiveness of Cilostazol After Endovascular Treatment of Femoropopliteal Lesions: Midterm Follow-up From the Sufficient Treatment of Peripheral Intervention by Cilostazol (STOP-IC) Study
  24. An Exploratory Study of Dapagliflozin for the Attenuation of Albuminuria in Patients with Heart Failure and Type 2 Diabetes Mellitus (DAPPER)
  25. Vascular response to biolimus A-9 eluting stent in patients with shorter and prolonged dual antiplatelet therapy: optical coherence tomography sub-study of the NIPPON trial
  26. Effect of eicosapentaenoic acid/docosahexaenoic acid on coronary high-intensity plaques detected with non-contrast T1-weighted imaging (the AQUAMARINE EPA/DHA study): study protocol for a randomized controlled trial
  27. Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan
  28. Rationale and Design of Low-dose Administration of Carperitide for Acute Heart Failure (LASCAR-AHF)
  29. Design, data monitoring, and analysis of clinical trials with co-primary endpoints: A review
  30. Metabolic tumor volume of primary tumor predicts survival better than T classification in the larynx preservation approach
  31. Antenatal antiarrhythmic treatment for fetal tachyarrhythmias: a study protocol for a prospective multicentre trial
  32. Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction?
  33. Sample size determination for a specific region in multiregional clinical trials with multiple co-primary endpoints
  34. Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms
  35. Dual Antiplatelet Therapy for 6 Versus 18 Months After Biodegradable Polymer Drug-Eluting Stent Implantation
  36. Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism
  37. A multicenter randomized controlled trial of surgery alone or surgery with atrial natriuretic peptide in lung cancer surgery: study protocol for a randomized controlled trial
  38. Does the pathophysiology of heart failure prime the incidence of cancer?
  39. A multicenter study of the need of additional freezing for cryoballoon ablation in patients with atrial fibrillation: The AD-Balloon study
  40. Low partial pressure of end-tidal carbon dioxide predicts left ventricular assist device implantation in patients with advanced chronic heart failure
  41. Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody
  42. Sizing clinical trials when comparing bivariate time-to-event outcomes
  43. Interview with Professor Geert Molenberghs
  44. Risk stratification based on nutritional screening on admission: Three-year clinical outcomes in hospitalized patients with acute heart failure syndrome
  45. Long-Term Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery
  46. Interim evaluation of efficacy or futility in group-sequential trials with multiple co-primary endpoints
  47. Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan
  48. Effectiveness of sarpogrelate after endovascular treatment for femoropopliteal artery disease: ESPALIER study
  49. Design and Rationale of the RELAXED (Recurrent Embolism Lessened by rivaroxaban, an Anti-Xa agent, of Early Dosing for acute ischemic stroke and transient ischemic attack with atrial fibrillation) Study
  50. Subclinical elevation of high-sensitive troponin T levels at the convalescent stage is associated with increased 5-year mortality after ST-elevation myocardial infarction
  51. Group-sequential three-arm noninferiority clinical trial designs
  52. Low total cholesterol and high total bilirubin are associated with prognosis in patients with prolonged sepsis
  53. Group-Sequential Clinical Trials with Multiple Co-Objectives
  54. Clinical Impact of Ventricular Tachycardia and/or Fibrillation During the Acute Phase of Acute Myocardial Infarction on In-Hospital and 5-Year Mortality Rates in the Percutaneous Coronary Intervention Era
  55. Regression analysis
  56. Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing’s disease and subclinical Cushing’s disease
  57. The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer
  58. Influence of the Lactotripeptides Isoleucine–Proline–Proline and Valine–Proline–Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  59. 3-Year Outcomes of the OLIVE Registry, a Prospective Multicenter Study of Patients With Critical Limb Ischemia
  60. The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin
  61. Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex
  62. Reducing unnecessary measurements in clinical trials with multiple primary endpoints
  63. Design and Evaluation of New Unified Criteria for Disseminated Intravascular Coagulation Based on the Japanese Association for Acute Medicine Criteria
  64. Sample Size Considerations in Clinical Trials When Comparing Two Interventions Using Multiple Co-Primary Binary Relative Risk Contrasts
  65. Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: A monoinstitutional study
  66. Ossification of the Posterior Longitudinal Ligament of the Cervical Spine in 3161 Patients
  67. Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis
  68. Postprocedural Skin Perfusion Pressure Correlates With Clinical Outcomes 1 Year After Endovascular Therapy for Patients With Critical Limb Ischemia
  69. B‐Type Natriuretic Peptide‐Guided Risk Assessment for Postoperative Complications in Lung Cancer Surgery
  70. Group-Sequential Strategies in Clinical Trials with Multiple Co-Primary Outcomes
  71. Sample Size Determination in Clinical Trials with Multiple Endpoints
  72. Two-sample tests for comparing means
  73. Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis
  74. Clinical significance of fluctuations in thyroid hormones after surgery for Cushing’s syndrome
  75. Group-Sequential Designs When Considering Two Binary Outcomes as Co-Primary Endpoints
  76. Analysis of survival data
  77. Fundamentals of statistical analysis in biomedical research:Avoiding statical pitfalls
  78. Multiple comparisons: comparing more than two treatments
  79. Two-sample tests for comparing proportions
  80. Different serial changes in the neointimal condition of sirolimus-eluting stents and paclitaxel-eluting stents: an optical coherence tomographic study
  81. Impact of alpha-fetoprotein on hepatocellular carcinoma development during entecavir treatment of chronic hepatitis B virus infection
  82. Outcomes of ESD for patients with early gastric cancer and comorbid liver cirrhosis: a propensity score analysis
  83. Design Challenges for Heart Failure Prevention Clinical Trials: Adaptive Design Approach
  84. Portable system for monitoring of regional cerebral oxygen saturation during prehospital cardiopulmonary resuscitation: a pilot study
  85. Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes
  86. Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study
  87. THrombolysis for Acute Wake-up and Unclear-Onset Strokes with Alteplase at 0·6 mg/kg (THAWS) Trial
  88. Difference in Left Ventricular Mass Index Between Hypertensive Patients With and Without Renal Artery Stenosis by Propensity Score Analysis
  89. Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy
  90. Comparison of 5-Year Survival After Acute Myocardial Infarction Using Angiotensin-Converting Enzyme Inhibitor Versus Angiotensin II Receptor Blocker
  91. Coronary triglyceride deposition in contemporary advanced diabetics
  92. Post-treatment Levels of α-Fetoprotein Predict Incidence of Hepatocellular Carcinoma After Interferon Therapy
  93. Uterine Cervical Cancer Displaying Tumor-Related Leukocytosis: A Distinct Clinical Entity With Radioresistant Feature
  94. Association of lifestyle-related factors with circadian onset patterns of acute myocardial infarction: a prospective observational study in Japan
  95. Importance of optimal local uterine blood flow for implantation
  96. Combination Treatment With Trabectedin and Irinotecan or Topotecan Has Synergistic Effects Against Ovarian Clear Cell Carcinoma Cells
  97. Possible modification of Alzheimer’s disease by statins in midlife: interactions with genetic and non-genetic risk factors
  98. Rapid and Sustained Long-Term Decrease of Fecal Short-Chain Fatty Acids in Critically Ill Patients With Systemic Inflammatory Response Syndrome
  99. Perioperative Landiolol Administration reduces Atrial Fibrillation after Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials
  100. Clinical impact of acute hyperglycemia on development of diabetes mellitus in non-diabetic patients with acute myocardial infarction
  101. Sample size determination in group‐sequential clinical trials with two co‐primary endpoints
  102. 11β-Hydroxysteroid Dehydrogenase 1 Specific Inhibitor Increased Dermal Collagen Content and Promotes Fibroblast Proliferation
  103. Altered balance of the aminogram in patients with sepsis – The relation to mortality
  104. Characterization of Patients With Angioscopically-Detected In-Stent Mural Thrombi
  105. Renin-Angiotensin-Aldosterone System Polymorphisms and 5-Year Mortality in Survivors of Acute Myocardial Infarction
  106. Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery
  107. Correction: Trends in the Prevalence of Tuberous Sclerosis Complex Manifestations: An Epidemiological Study of 166 Japanese Patients
  108. Outcome prediction model for severe traumatic brain injury
  109. Synovial joint fluid cytokine levels in hip disease
  110. Living alone and risk of cardiovascular events following discharge after acute myocardial infarction in Japan
  111. Response to the Letter by Devaux et al
  112. Authors’ reply
  113. Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction
  114. Maximal Chemiluminescent Intensity in Response to Lipopolysaccharide Assessed by Endotoxin Activity Assay on Admission Day Predicts Mortality in Patients With Sepsis*
  115. Trends in the Prevalence of Tuberous Sclerosis Complex Manifestations: An Epidemiological Study of 166 Japanese Patients
  116. Cilostazol Reduces Angiographic Restenosis After Endovascular Therapy for Femoropopliteal Lesions in the Sufficient Treatment of Peripheral Intervention by Cilostazol Study
  117. Partition testing in confirmatory adaptive designs with structured objectives
  118. Sleep quality in patients with alopecia areata: questionnaire-based study
  119. L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson’s disease
  120. Impact of Beta Blockade Therapy on Long-Term Mortality After ST-Segment Elevation Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era
  121. Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis
  122. Endovascular Treatment for Infrainguinal Vessels in Patients With Critical Limb Ischemia: OLIVE Registry, a Prospective, Multicenter Study in Japan With 12-Month Follow-up
  123. A logrank test-based method for sizing clinical trials with two co-primary time-to-event endpoints
  124. Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization
  125. Statistical Issues in Clinical Trials with Multiple Primary Endpoints
  126. Incidence, Predictors, and Subsequent Mortality Risk of Recurrent Myocardial Infarction in Patients Following Discharge for Acute Myocardial Infarction
  127. Impact on survival of whole-body computed tomography before emergency bleeding control in patients with severe blunt trauma
  128. DNA Damage in Rheumatoid Arthritis: An Age-Dependent Increase in the Lipid Peroxidation-Derived DNA Adduct, Heptanone-Etheno-2′-Deoxycytidine
  129. Clinical Features of Young Patients with Olfactory Disorders
  130. Reduction of Thoracic Aorta Motion Artifact With High-Pitch 128-Slice Dual-Source Computed Tomographic Angiography
  131. Parkinsonian Rigidity Shows Variable Properties Depending on the Elbow Joint Angle
  132. Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice
  133. Fast Wavelength Switching of Fully Heater-tuned CSG-DR Lasers
  134. Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Outcome in Patients Surviving Acute Myocardial Infarction
  135. Low Levels of Serum n-3 Polyunsaturated Fatty Acids Are Associated With Worse Heart Failure-Free Survival in Patients After Acute Myocardial Infarction
  136. Sample size determination for clinical trials with co‐primary outcomes: exponential event times
  137. A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
  138. Elevated White Blood Cell Count at the Time of Recurrence Diagnosis Is an Indicator of Short Survival in Patients With Recurrent Cervical Cancer
  139. Is the transverse acetabular ligament a reliable cup orientation guide?
  140. INTRAOCULAR PRESSURE ELEVATION IS A DELAYED-ONSET COMPLICATION AFTER SUCCESSFUL VITRECTOMY FOR STAGES 4 AND 5 RETINOPATHY OF PREMATURITY
  141. Adiponectin negatively correlates with alcoholic and non‐alcoholic liver dysfunction: Health check‐up study of Japanese men
  142. Sample size determination in clinical trials with multiple co-primary endpoints including mixed continuous and binary variables
  143. Estimation of mouse fetal weight by ultrasonography: application from clinic to laboratory
  144. How Regular Visits and Preventive Programs Affect Onset of Adult Caries
  145. Prediction of Progression-Free Survival and Response to Paclitaxel Plus Carboplatin in Patients With Recurrent or Advanced Cervical Cancer
  146. Recombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis
  147. A convenient formula for sample size calculations in clinical trials with multiple co‐primary continuous endpoints
  148. Clinical Outcomes and Changes in Aqueous Vascular Endothelial Growth Factor Levels After Intravitreal Bevacizumab for Iris Neovascularization and Neovascular Glaucoma: A Retrospective Two-Dose Comparative Study
  149. Prognostic impact of fecal pH in critically ill patients
  150. Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction
  151. Assessment of risk factors related to healthcare-associated methicillin-resistant Staphylococcus aureus infection at patient admission to an intensive care unit in Japan
  152. Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups
  153. P3‐403: Cognitive training on elderly japanese in osaka: Major outcome (ADAS) from prospective, randomized, open, blind‐endpoint trial
  154. Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer
  155. Prognostic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: The Utstein Osaka Project
  156. Risk assessment of dental caries by using Classification and Regression Trees
  157. Pre-emptive contact precautions for intubated patients reduced healthcare-associated meticillin-resistant Staphylococcus aureus transmission and infection in an intensive care unit
  158. Hybridization of magnetic excitations between quasi-one-dimensional spin chains and spin dimers in Cu 3 Mo 2 O 9 observed using inelastic neutron scattering
  159. Sample Size Determination in Superiority Clinical Trials with Multiple Co-Primary Correlated Endpoints
  160. Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis
  161. Clinical Trials, History of
  162. A simple modification of the Box and Cox transformation to scale stability and invariance
  163. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study
  164. A Note on Analysis of Ratio of Two Correlated Normal Variables
  165. Multicenter Survey with a Systematic Overview of Acute-Onset Endophthalmitis after Transconjunctival Microincision Vitrectomy Surgery
  166. Altered Gut Flora Are Associated with Septic Complications and Death in Critically Ill Patients with Systemic Inflammatory Response Syndrome
  167. Macular Pigment Optical Density in Central Serous Chorioretinopathy
  168. Sample size determination in clinical trials with multiple co‐primary binary endpoints
  169. Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma
  170. Practical issues and lessons learned from multi‐regional clinical trials via case examples: a Japanese perspective
  171. O3‐04‐07: Cognitive training on elderly Japanese in Osaka: Major outcome (ADAS) from prospective, randomized, open, blind‐endpoint trial
  172. Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia
  173. Practical application of cure mixture model for long-term censored survivor data from a withdrawal clinical trial of patients with major depressive disorder
  174. Reduced carotid atherosclerosis in asthmatic patients treated with inhaled corticosteroids
  175. Box and Cox power-transformation to additivity and homoscedasticity in regression
  176. <i>KIBRA</i> Genetic Polymorphism Influences Episodic Memory in Alzheimer’s Disease, but Does Not Show Association with Disease in a Japanese Cohort
  177. Intravitreal Bevacizumab vs Sub-Tenon Triamcinolone Acetonide for Choroidal Neovascularization Attributable to Pathologic Myopia
  178. Immunotherapy of ovarian cancer with cell wall skeleton of Mycobacterium bovis Bacillus Calmette‐Guérin: Effect of lymphadenectomy
  179. Influence of voluntary control of masticatory side and rhythm on cerebral hemodynamics
  180. Opening velocity, a novel parameter, for finger tapping test in patients with Parkinson's disease
  181. A quantitative characterization of postural sway during human quiet standing using a thin pressure distribution measurement system
  182. Prognostic Indicators and Outcome Prediction Model for Severe Traumatic Brain Injury
  183. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials
  184. Task-induced activation and hemispheric dominance in cerebral circulation during gum chewing
  185. HLA-DR-negative AML (M1 and M2): FLT3 mutations (ITD and D835) and cell-surface antigen expression
  186. Box and Cox power-transformation to confined and censored nonnormal responses in regression
  187. A COMPARISON OF METHODS FOR PARAMETER ESTIMATION OF THE SHIFTED POWER TRANSFORMATION
  188. The Role of Randomization in Clinical Trials
  189. Properties of estimators of baseline hazard functions in a semiparametric cure model
  190. A placebo-controlled, randomized withdrawal study of sertraline for major depressive disorder in Japan
  191. A Digital Input Controller for Audio Class-D Amplifiers with 100W 0.004% THD+N and 113dB DR
  192. Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats
  193. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS
  194. A placebo-controlled, randomized withdrawal study of sertraline for panic disorder in Japan
  195. POWER-TRANSFORMATION MODEL TO ADDITIVITY IN REGRESSION
  196. ASYMPTOTIC PROPERTIES OF ESTIMATES OF THE POWER-TRANSFORMATION MODEL TO BIVARIATE GROUPED DATA
  197. ESTIMATION FROM PSEUDO PARTIAL LIKELIHOOD IN A SEMIPARAMETRIC CURE MODEL
  198. Benefit of valproic acid in suppressing disease progression of ALS model mice
  199. 2. Clinical and Medical Evaluation Process
  200. SIMULTANEOUS DIAGNOSTIC METHODS FOR THE DOUBLE POWER-NORMAL TRANSFORMATION MODEL
  201. PRACTICAL ISSUES AND OBSERVATIONS ON THE USE OF FOREIGN CLINICAL DATA IN DRUG DEVELOPMENT
  202. STATISTICAL INFERENCES OF GROUPED DATA COMBINED WITH UNGROUPED DATA FROM THE POWER-NORMAL DISTRIBUTION
  203. On Inferences of Parameters in the Bivariate Power-Normal Distribution
  204. Statistical Approaches to Detecting Dose-Response Relationships
  205. INFERENCES BASED ON THE GROUPED OBSERVATIONS FROM THE BIVARIATE POWER-NORMAL DISTRIBUTION
  206. Fitting power normal distribution to grouped observations
  207. Autostereoscopic 3‐D television experiments
  208. Launch, Tracking and Control