All Stories

  1. Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains
  2. Constructing an In Silico Three-Class Predictor of Human Intestinal Absorption With Caco-2 Permeability and Dried-DMSO Solubility
  3. Computational Model To Predict the Fraction of Unbound Drug in the Brain
  4. Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing
  5. Assessing drug target suitability using TargetMine
  6. B cell‐intrinsic MyD88 signaling controls IFN‐γ‐mediated early IgG2c class switching in mice in response to a particulate adjuvant
  7. Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein
  8. Assessing drug target suitability using TargetMine
  9. Integrative Analysis of Multi-Omics Data
  10. Network-Based Analysis for Biological Discovery
  11. Network-Based Analysis of Host-Pathogen Interactions
  12. Data Warehousing with TargetMine for Omics Data Analysis
  13. High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives
  14. Predicting Fraction Unbound in Human Plasma from Chemical Structure: Improved Accuracy in the Low Value Ranges
  15. Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance
  16. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging
  17. An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8+T Cells in Nonhuman Primates
  18. Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism
  19. Essential Role of CARD14 in Murine Experimental Psoriasis
  20. PSOPIA: Toward more reliable protein-protein interaction prediction from sequence information
  21. Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data
  22. Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity
  23. Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences
  24. Editorial—Sequences and topology
  25. Network analysis and in silico prediction of protein–protein interactions with applications in drug discovery
  26. A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
  27. Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates
  28. Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody
  29. Computational systems biology for drug discovery: from molecules, structures to networks
  30. Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine
  31. Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration
  32. Improved pose and affinity predictions using different protocols tailored on the basis of data availability
  33. Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
  34. The diversity of H3 loops determines the antigen-binding tendencies of antibody CDR loops
  35. An integrative data analysis platform for gene set analysis and knowledge discovery in a data warehouse framework
  36. Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis
  37. Critical Assessment of inhibitors identification followed by wet confirmation
  38. Systems Biology Approaches to a Rational Drug Discovery Paradigm
  39. Integration of Ligand and Structure Based Approaches for CSAR-2014
  40. Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence
  41. Genome-wide transcription factor activities are explained by intrinsic conformational dynamics of binding-sites and distal flanking-regions
  42. BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells
  43. Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing
  44. Two distinct effector memory cell populations of WT1 (Wilms’ tumor gene 1)-specific cytotoxic T lymphocytes in acute myeloid leukemia patients
  45. Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing
  46. Integration of Disease Entries Across OMIM, Orphanet, and a Proprietary Knowledge Base
  47. Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line
  48. PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs
  49. Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein
  50. Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators
  51. Integrated Pathway Clusters with Coherent Biological Themes for Target Prioritisation
  52. High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations
  53. Crystal structure of FtsA fromStaphylococcus aureus
  54. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
  55. Prediction of Detailed Enzyme Functions and Identification of Specificity Determining Residues by Random Forests
  56. Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) is predicted to interact with its partner through an ARM-type α-helical structure
  57. Conformational changes in DNA‐binding proteins: Relationships with precomplex features and contributions to specificity and stability
  58. Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells
  59. Toxygates: interactive toxicity analysis on a hybrid microarray and linked data platform
  60. Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistantStaphylococcus aureus
  61. Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid A gene promoter
  62. Understanding the Biological Context of NS5A–Host Interactions in HCV Infection: A Network-Based Approach
  63. Functional site plasticity in domain superfamilies
  64. The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant
  65. A combined proteomics and computational approach provides a better understanding of HCV-induced liver disease
  66. Computational design, construction, and characterization of a set of specificity determining residues in protein-protein interactions
  67. Proteomic Analysis of Hepatitis C Virus (HCV) Core Protein Transfection and Host Regulator PA28γ Knockout in HCV Pathogenesis: A Network-Based Study
  68. Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis
  69. Identification and classification of bacterial Type III toxin–antitoxin systems encoded in chromosomal and plasmid genomes
  70. An Open Framework for Extensible Multi-stage Bioinformatics Software
  71. Sagace: A web-based search engine for biomedical databases in Japan
  72. Partner-Aware Prediction of Interacting Residues in Protein-Protein Complexes from Sequence Data
  73. Using Knowledge of Protein Structural Constraints to Predict the Evolution of HIV-1
  74. TargetMine, an Integrated Data Warehouse for Candidate Gene Prioritisation and Target Discovery
  75. Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity
  76. Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data
  77. Prediction of dinucleotide-specific RNA-binding sites in proteins
  78. Integrated prediction of one-dimensional structural features and their relationships with conformational flexibility in helical membrane proteins
  79. Detecting subtle functional differences in ketopantoate reductase and related enzymes using a rule-based approach with sequence-structure homology recognition scores
  80. A structural dissection of amino acid substitutions in helical transmembrane proteins
  81. On nucleotide solvent accessibility in RNA structure
  82. Applying the Naïve Bayes classifier with kernel density estimation to the prediction of protein–protein interaction sites
  83. Relationships between functional subclasses and information contained in active-site and ligand-binding residues in diverse superfamilies
  84. CCRXP: exploring clusters of conserved residues in protein structures
  85. Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system
  86. Network based analysis of hepatitis C virus Core and NS4B protein interactions
  87. Lipophobicity and the residue environments of the transmembrane α-helical bundle
  88. Prediction of mono- and di-nucleotide-specific DNA-binding sites in proteins using neural networks
  89. Distinct protein interfaces in transmembrane domains suggest an in vivo folding model
  90. Molecular Basis for SUMOylation-dependent Regulation of DNA Binding Activity of Heat Shock Factor 2
  91. Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation
  92. Docking of cytochrome c6 and plastocyanin to the aa3-type cytochrome c oxidase in the cyanobacterium Phormidium laminosum
  93. A phylogenomic profile of hemerythrins, the nonheme diiron binding respiratory proteins
  94. Benchmarking and analysis of DNA-binding site prediction using machine learning
  95. Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor
  96. A model of globin evolution
  97. Environment specific substitution tables for thermophilic proteins
  98. FlyMine: an integrated database for Drosophila and Anopheles genomics
  99. The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97
  100. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
  101. A novel mechanism of allosteric regulation of archaeal phosphoenolpyruvate carboxylase: a combined approach to structure-based alignment and model assessment
  102. The guanidino-group modifying enzymes: Structural basis for their diversity and commonality
  103. Organic Anion Transporting Polypeptides of the OATP/SLCO Superfamily: Identification of New Members in Nonmammalian Species, Comparative Modeling and a Potential Transport Mode
  104. Functional restraints on the patterns of amino acid substitutions: Application to sequence-structure homology recognition
  105. A model of a transmembrane drug-efflux pump from Gram-negative bacteria
  106. Fold recognition for drug discovery
  107. HOMSTRAD: recent developments of the Homologous Protein Structure Alignment Database
  108. Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism
  109. The Export of Coat Protein from EnteroaggregativeEscherichia coliby a Specific ATP-binding Cassette Transporter System
  110. Cylindrical Channels from Concave Helices
  111. Structure of the periplasmic domain of Pseudomonasaeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein
  112. The SWIB and the MDM2 domains are homologous and share a common fold
  113. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in theDrosophilagenome
  114. A novel superfamily of enzymes that catalyze the modification of guanidino groups
  115. HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families
  116. FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties11Edited by B. Honig
  117. Analysis of the segmental stability of helical peptides by isotope-edited infrared spectroscopy
  118. Sequence-structure homology recognition by iterative alignment refinement and comparative modeling
  119. Analysis of conservation and substitutions of secondary structure elements within protein superfamilies
  120. Structural genomics: an overview
  121. β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
  122. Characterisation of the gene for Drosophila amphiphysin
  123. N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi β-barrel aspartate decarboxylase/formate dehydrogenase family
  124. The Insulin Receptor: from Protein Sequence to Structure
  125. A six-stranded double-psi β barrel is shared by several protein superfamilies
  126. An iterative structure‐assisted approach to sequence alignment and comparative modeling
  127. A third fibronectin type III domain in the extracellular region of the insulin receptor family
  128. Protein Three-Dimensional Structural Databases: Domains, Structurally Aligned Homologues and Superfamilies
  129. HOMSTRAD: A database of protein structure alignments for homologous families
  130. CAMPASS: a database of structurally aligned protein superfamilies
  131. Erratum—Getting knotted: a model for the structure and activation of Spätzle
  132. JOY: protein sequence-structure representation and analysis
  133. Getting knotted: a model for the structure and activation of Spätzle
  134. Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins
  135. Seeking significance in three-dimensional protein structure comparisons
  136. Comparison of spatial arrangements of secondary structural elements in proteins
  137. Collective motions in proteins investigated by X-ray diffuse scattering