All Stories

  1. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library

    Article • European Journal of Medicinal Chemistry, December 2022, Elsevier

    Dr Ernesto Quesada

  2. Antinociceptive and modulatory effect of pathoplastic changes in spinal glia of a TLR4/CD14 blocking molecule in two models of pain in rat

    Article • Biomedicine & Pharmacotherapy, June 2022, Elsevier

    Dr Ernesto Quesada

  3. Pradimicin and Benanomicin Antibiotics: From Antifungal Polyketide Natural Products to Antiviral Agents with a Unique Carbohydrate- Binding Mode of Action

    Article • November 2021, Bentham Science Publishers

    Dr Ernesto Quesada

  4. TLR4 Antagonism Reduces Movement-Induced Nociception and ATF-3 Expression in Experimental Osteoarthritis

    Article • Journal of Pain Research, August 2021, Taylor & Francis

    Dr Ernesto Quesada

  5. Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors

    Article • Journal of Medicinal Chemistry, July 2021, American Chemical Society (ACS)

    Dr Ernesto Quesada, Johan Neyts

  6. A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Johan Neyts, Dr Ernesto Quesada

  7. Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity

    Article • European Journal of Medicinal Chemistry, March 2018, Elsevier

    Dr Ernesto Quesada

  8. SAT0494 Early toll-like receptor 4 blockade impedes the behavioural and histological characteristics observed in a mia-induced animal model of osteoarthritic pain

    Article • June 2017, BMJ

    Dr Ernesto Quesada

  9. AB0043 TLR4 inhibition reduces movement-induced nociception and ATF-3 expression in experimental osteoarthritis

    Article • June 2017, BMJ

    Dr Ernesto Quesada

  10. Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid

    Article • Antiviral Research, March 2017, Elsevier

    Johan Neyts, Dr Ernesto Quesada

  11. Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

    Article • Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals

    Dr. ANA SAN-FELIX, Johan Neyts, Dr Ernesto Quesada

  12. Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers

    Article • European Journal of Medicinal Chemistry, December 2015, Elsevier

    Dr Ernesto Quesada

  13. Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41

    Article • European Journal of Medicinal Chemistry, December 2015, Elsevier

    Dr Ernesto Quesada

  14. Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

    Article • European Journal of Medicinal Chemistry, March 2015, Elsevier

    Johan Neyts, Dr Ernesto Quesada

  15. Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Dr Ernesto Quesada

  16. Entry Inhibitors Directed Towards Glycoprotein gp120: An Overview on a Promising Target for HIV-1 Therapy

    Article • Current Medicinal Chemistry, February 2013, Bentham Science Publishers

    Dr Ernesto Quesada

  17. Differential Recognition of Mannose-Based Polysaccharides by Tripodal Receptors Based on a Triethylbenzene Scaffold Substituted with Trihydroxybenzoyl Moieties

    Article • European Journal of Organic Chemistry, November 2012, Wiley

    Dr Ernesto Quesada

  18. Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides

    Article • Antiviral Research, October 2011, Elsevier

    Dr Ernesto Quesada

  19. One-Pot Synthesis of Polycyclic Nucleosides with Unusual Molecular Skeletons

    Article • The Journal of Organic Chemistry, December 2009, American Chemical Society (ACS)

    Dr Ernesto Quesada

  20. Novel N-3 Substituted TSAO-T Derivatives: Synthesis and Anti-HIV-Evaluation

    Article • Nucleosides Nucleotides & Nucleic Acids, April 2008, Taylor & Francis

    Dr Ernesto Quesada

  21. Synthesis of Highly Condensed Polycyclic Carbohydrates by Reaction of a Spirocyclic Enamino Sulfonate Derived fromd-Xylofuranose with Bifunctional Reagents

    Article • The Journal of Organic Chemistry, December 2007, American Chemical Society (ACS)

    Dr Ernesto Quesada

  22. Synthesis and Spectral Properties of Amphiphilic Lipids with Linear Conjugated Polyene and Phenylpolyene Fluorescent Groups

    Article • European Journal of Organic Chemistry, May 2007, Wiley

    Dr Ernesto Quesada

  23. A Cyclic Enamine Derived from 1,2-O-Isopropylidene-α-d-xylofuranose As a Novel Carbohydrate Intermediate To Achieve Skeletal Diversity

    Article • The Journal of Organic Chemistry, September 2006, American Chemical Society (ACS)

    Dr Ernesto Quesada

  24. One-pot conversion of activated alcohols into 1,1-dibromoalkenes and terminal alkynes using tandem oxidation processes with manganese dioxide

    Article • Tetrahedron, July 2006, Elsevier

    Dr Ernesto Quesada

  25. Dynamics of bolaamphiphilic fluorescent polyenes in lipid bilayers from polarization emission spectroscopy

    Article • Biophysical Chemistry, June 2006, Elsevier

    Dr Ernesto Quesada

  26. One-pot conversion of activated alcohols into terminal alkynes using manganese dioxide in combination with the Bestmann–Ohira reagent

    Article • Tetrahedron Letters, September 2005, Elsevier

    Dr Ernesto Quesada

  27. Tandem Horner-Wadsworth-Emmons Olefination/Claisen Rearrangement/Hydrolysis Sequence: Remarkable Acceleration in Water with Microwave Irradiation

    Article • Synthesis, January 2005, Thieme Publishing Group

    Dr Ernesto Quesada

  28. Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

    Article • Journal of Medicinal Chemistry, October 2004, American Chemical Society (ACS)

    Dr Ernesto Quesada

  29. The first total syntheses of (±)-Preussomerins K and L using 2-arylacetal anion technology

    Article • Tetrahedron Letters, June 2004, Elsevier

    Dr Ernesto Quesada

  30. A versatile, non-biomimetic route to the preussomerins: syntheses of (±)-preussomerins F, K and L

    Article • Organic & Biomolecular Chemistry, January 2004, Royal Society of Chemistry

    Dr Ernesto Quesada

  31. Leads for Development of New Naphthalenesulfonate Derivatives with Enhanced Antiangiogenic Activity: CRYSTAL STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR IN COMPLEX WITH 5-AMINO-2-NAPHTHALENESULFONATE

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Guillermo Gimenez-Gallego, Dr Ernesto Quesada

  32. Synthesis of Carboxyl-Tethered Symmetric Conjugated Polyenes as Fluorescent Transmembrane Probes of Lipid Bilayers

    Article • European Journal of Organic Chemistry, March 2003, Wiley

    Dr Ernesto Quesada

  33. New Transmembrane Polyene Bolaamphiphiles as Fluorescent Probes in Lipid Bilayers

    Article • Angewandte Chemie International Edition, June 2001, Wiley

    Dr Ernesto Quesada

  34. New Transmembrane Polyene Bolaamphiphiles as Fluorescent Probes in Lipid Bilayers

    Article • Angewandte Chemie International Edition, June 2001, Wiley

    Dr Ernesto Quesada

  35. Synthesis and Fluorescence Properties of Novel Transmembrane Probes and Determination of Their Orientation within Vesicles

    Article • Helvetica Chimica Acta, September 2000, Wiley

    Dr Ernesto Quesada

  36. Synthesis of Crowned Triazolephthalocyanines

    Article • European Journal of Organic Chemistry, August 2000, Wiley

    Dr Ernesto Quesada