All Stories

  1. The Carboxy-Terminal Domain of ROS1 Is Essential for 5-Methylcytosine DNA Glycosylase Activity

    Article • Journal of Molecular Biology, November 2014, Elsevier

    Dr Hideharu Hashimoto

  2. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence

    Article • Genes & Development, September 2014, Cold Spring Harbor Laboratory Press

    Dr Hideharu Hashimoto

  3. Structural basis for Klf4 recognition of methylated DNA

    Article • Nucleic Acids Research, February 2014, Oxford University Press (OUP)

    Dr Hideharu Hashimoto

  4. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

    Article • Journal of Medicinal Chemistry, January 2014, American Chemical Society (ACS)

    Dr Hideharu Hashimoto, Professor Marc Diederich, Dr Michael Schnekenburger

  5. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA

    Article • Nature, December 2013, Springer Science + Business Media

    Dr Hideharu Hashimoto

  6. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH

    Article • DNA Repair, July 2013, Elsevier

    Dr Hideharu Hashimoto

  7. Selective Excision of 5-Carboxylcytosine by a Thymine DNA Glycosylase Mutant

    Article • Journal of Molecular Biology, March 2013, Elsevier

    Dr Hideharu Hashimoto

  8. Structural Insights into the Substrate Recognition by TDG Glycosylase Domain and MBD4 Glycosylase Domain

    Article • Seibutsu Butsuri, January 2013, Biophysical Society of Japan

    Dr Hideharu Hashimoto

  9. Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

    Article • Nucleic Acids Research, September 2012, Oxford University Press (OUP)

    Dr Hideharu Hashimoto

  10. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation

    Article • Nucleic Acids Research, June 2012, Oxford University Press (OUP)

    Dr Hideharu Hashimoto

  11. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

    Article • Nucleic Acids Research, February 2012, Oxford University Press (OUP)

    Dr Hideharu Hashimoto

  12. Structural Basis for Human PHF2 Jumonji Domain Interaction with Metal Ions

    Article • Journal of Molecular Biology, February 2011, Elsevier

    Dr Hideharu Hashimoto

  13. Mechanisms of DNA Methylation, Methyl-CpG Recognition, and Demethylation in Mammals

    Article • January 2011, Elsevier

    Dr Hideharu Hashimoto

  14. Molecular coupling of DNA methylation and histone methylation

    Article • Epigenomics, October 2010, Future Medicine

    Dr Hideharu Hashimoto

  15. Histone H1 null vertebrate cells exhibit altered nucleosome architecture

    Article • Nucleic Acids Research, February 2010, Oxford University Press (OUP)

    Dr Hideharu Hashimoto

  16. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

    Article • Epigenetics, January 2009, Taylor & Francis

    Dr Hideharu Hashimoto

  17. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

    Article • Nature, September 2008, Springer Science + Business Media

    Dr Hideharu Hashimoto

  18. Histone H1 variant, H1R is involved in DNA damage response

    Article • DNA Repair, November 2007, Elsevier

    Dr Hideharu Hashimoto

  19. Rad54 is dispensable for the ALT pathway

    Article • Genes to Cells, October 2006, Wiley

    Dr Hideharu Hashimoto

  20. Monoclonal antibody against dnmt1 arrests the cell division of xenopus early-stage embryos

    Article • Experimental Cell Research, June 2003, Elsevier

    Dr Hideharu Hashimoto